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Updated: Dec 3, 2025

Synthesis of 1,2-Azaborines and the Preparation of Their Protein Complexes with T4 Lysozyme Mutants
Published on: March 25, 2017
A practical base mediated synthesis of 1,2,4-triazoles enabled by a deamination annulation strategy
Chunyan Zhang1, Zuyu Liang, Xiaofei Jia
1Key Laboratory of Sensor Analysis of Tumor Marker, Ministry of Education, Shan-dong Key Laboratory of Biochemical Analysis, Key Laboratory of Analytical Chem-istry for Life Science in Universities of Shandong, Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China. zhanggy@qust.edu.cn.
Abstract:
A rapid and efficient base mediated synthesis of 1,3,5-trisubstituted 1,2,4-triazoles has been developed using the annulation of nitriles with hydrazines, which can be expanded to a wide range of triazoles in good to excellent yields. Ammonia gas is liberated during the reaction, and halo and hetero functional groups as well as free hydroxyl and amino groups are tolerated in this transformation. A variety of alkyl and aryl-substituted nitriles can be functionalized with aromatic and aliphatic hydrazines employing this procedure. This finding provides a practical and useful strategy for the synthesis of various 15N-labeled 1,2,4-triazole derivatives, and two types of mGlu5 receptor pharmaceuticals can be easily assembled in a one-pot manner.
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