Related Experiment Video
Updated: Dec 3, 2025
06:21
Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
Published on: May 10, 2024
1.0K
Cyclin D1 G870A Polymorphism: Relation to the Risk of ALL Development, Prognosis Impact, and Methotrexate
Nadia El Menshawy1, Ahmed B El Marghany1, Mohamed M Sarhan2
1Hematology Unit, Department of Clinical Pathology, Mansoura University, Egypt.
Asian Pacific Journal of Cancer Prevention : APJCP
|October 28, 2020
Summary
The CCND1 G870A gene polymorphism increases the risk of developing acute lymphoblastic leukemia (ALL). However, this CCND1 variant does not impact ALL prognosis or methotrexate treatment effectiveness.
Area of Science:
- Genetics
- Oncology
- Pharmacogenomics
Background:
- Cyclin D1 (CCND1) is crucial for cell cycle regulation and methotrexate metabolism.
- CCND1 gene polymorphism was investigated for its potential role in acute lymphoblastic leukemia (ALL).
Purpose of the Study:
- To investigate the association between CCND1 G870A polymorphism and ALL development.
- To evaluate the impact of CCND1 polymorphism on ALL prognosis and methotrexate cytotoxicity.
Main Methods:
- Genotyping of CCND1 G870A polymorphism using PCR-RFLP in 50 ALL patients and 50 controls.
- Assessment of methotrexate cytotoxicity via liver function tests.
- One-year follow-up for disease-free survival (DFS) and overall survival (OS).
Main Results:
- The AA genotype and A allele of CCND1 G870A were associated with an increased risk of ALL.
- No significant association was found between CCND1 polymorphism and methotrexate cytotoxicity.
- CCND1 polymorphism did not demonstrate a role in predicting ALL prognosis.
Conclusions:
- CCND1 G870A polymorphism is linked to a higher risk of developing ALL.
- The CCND1 G870A variant does not influence ALL prognosis or response to methotrexate therapy.
More Related Videos
Related Concept Videos
01:25Mutagenicity and Carcinogenicity
1.7K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.7K
02:39Positive Regulator Molecules
6.3K
Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
6.3K
02:15M-Cdk Drives Transition Into Mitosis
6.0K
Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
6.0K
02:23Abnormal Proliferation
4.9K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.9K
02:34Inhibition of Cdk Activity
5.4K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
5.4K
01:33Cancer-Critical Genes I: Proto-oncogenes
10.4K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
10.4K