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Updated: Dec 3, 2025
Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
Published on: January 29, 2014
A case of megaloblastic anemia simulating a cold autoimmune hemolytic anemia
Rosalía De La Puerta1, Nelly Carpio2, Guillermo Sanz3
1Fellow in Hematology and Hemotherapy, Hematology Department, Hospital Universitari I Politècnic La Fe.
Conclusions:
We report a case of pernicious anemia in which the first diagnosis suspicion was cold autoimmune hemolytic anemia (cAIHA) due to the presence of cold autoantibodies. A 47-year-old woman with a medical history of autoimmune thyroid disease came to the hospital with a clinical and serologic presentation of AIHA. However, because of determination of vitamin B12 (VB12) deficiency, she was finally diagnosed with megaloblastic anemia. In the acute period, the patient received short-term corticosteroid therapy and later VB12. The patient's hemoglobin level and general condition showed improvement.
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