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Generation of Alginate Microspheres for Biomedical Applications
Published on: August 12, 2012
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Alginate Nanoformulation: Influence of Process and Selected Variables
Hazem Choukaife1, Abd Almonem Doolaanea2, Mulham Alfatama1
1Faculty of Pharmacy, Universiti Sultan Zainal Abidin, Besut Campus, Terengganu 22200, Malaysia.
Pharmaceuticals (Basel, Switzerland)
|October 29, 2020
Summary
Biodegradable polymeric nanocarriers, particularly alginate nanoparticles, offer enhanced drug delivery by improving stability and enabling controlled release. Manufacturing techniques significantly impact their properties for effective biomedical applications.
Area of Science:
- Biomedical Engineering
- Materials Science
- Pharmaceutical Sciences
Background:
- Nanocarriers, utilizing nanomaterials, enhance drug delivery through improved solubility, stability, and bioavailability.
- Biodegradable polymers like polysaccharides are crucial for designing effective drug delivery systems.
- Alginate is a promising biopolymer for nanocarrier formulation due to its biocompatibility and biodegradability.
Purpose of the Study:
- To review manufacturing techniques for alginate-based nanoparticulate delivery systems.
- To summarize the effects of processing and formulation parameters on alginate nanoparticles.
- To highlight the potential of alginate nanocarriers in controlled drug delivery.
Main Methods:
- Emulsification/gelation complexation
- Layer-by-layer assembly
- Spray drying
- Electrospray
- Electrospinning
Main Results:
- Various techniques exist for synthesizing alginate nanoparticles with tailored properties.
- Processing parameters critically influence the characteristics of alginate nanoparticles.
- Alginate nanocarriers facilitate controlled drug release and site-specific targeting.
Conclusions:
- Alginate nanoparticles are effective for controlled drug delivery, reducing dosing frequency and prolonging therapeutic effects.
- Selection of appropriate biopolymer and manufacturing technique is essential for optimal nanocarrier performance.
- Further research into manufacturing techniques can lead to more efficient and cost-effective alginate-based delivery systems.
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