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Using Brain Activation nir-HEG/Q-EEG and Execution Measures CPTs in a ADHD Assessment Protocol
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Role of Oxidative Stress and Neuroinflammation in Attention-Deficit/Hyperactivity Disorder

Juan Carlos Corona1

  • 1Laboratory of Neurosciences, Hospital Infantil de México Federico Gómez, Mexico City 06720, Mexico.

Antioxidants (Basel, Switzerland)
|October 29, 2020
PubMed

Insights

Attention-deficit/hyperactivity disorder (ADHD) is linked to increased oxidative stress and neuroinflammation. Natural antioxidants may offer potential new treatments for ADHD by targeting these pathways.

Area of Science:

  • Neuroscience
  • Biochemistry

Background:

  • Attention-deficit/hyperactivity disorder (ADHD) is a complex neurodevelopmental disorder with multifactorial origins.
  • While brain region abnormalities and catecholaminergic pathway disturbances are known, the exact pathophysiology remains unclear.
  • Emerging evidence links ADHD to increased oxidative stress and neuroinflammation.

Purpose of the Study:

  • To review factors contributing to oxidative stress and neuroinflammation in ADHD.
  • To explore the potential of natural antioxidants as therapeutic agents for ADHD.

Main Methods:

  • Literature review of studies investigating oxidative stress and neuroinflammation in ADHD.
  • Analysis of factors influencing oxidant-antioxidant balance and inflammatory processes in ADHD.
  • Examination of genetic, environmental, and comorbidity associations.

Main Results:

  • Oxidative damage in ADHD can be exacerbated by oxidant-antioxidant imbalance and certain medications.
  • Neuroinflammation in ADHD is associated with comorbidities, immune response alterations, and genetic factors.
  • Specific polymorphisms in inflammatory-related genes may play a role in ADHD pathogenesis.

Conclusions:

  • Oxidative stress and neuroinflammation are significant contributing factors to ADHD pathophysiology.
  • Understanding these mechanisms opens avenues for novel therapeutic strategies.
  • Natural antioxidants show promise for managing oxidative stress and neuroinflammation in ADHD patients.

Keywords:
attention-deficit/hyperactivity disorder (ADHD)medicationsneuroinflammationoxidative stress

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