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Relationship of Plasma Vitamin-D Level with Left Ventricular Ejection Fraction in Patients with First Attack of Acute
M M Islam1, J U Sharif, S Khan
1Professor Dr Mirza Md Nazrul Islam, Professor, Department of Cardiology, Mymensingh Medical College (MMC), Mymensingh, Bangladesh.
Insights
Low vitamin D levels are linked to reduced Left Ventricular Ejection Fraction (LVEF) in patients experiencing their first acute Myocardial Infarction (MI). This finding highlights vitamin D
Area of Science:
- Cardiology
- Endocrinology
- Nutritional Science
Background:
- Vitamin D deficiency is increasingly recognized as a potential contributing factor to Coronary Heart Disease (CHD), particularly acute Myocardial Infarction (MI).
- Reduced Left Ventricular Ejection Fraction (LVEF) is a critical indicator of cardiac function post-MI, and its determinants require thorough investigation.
Purpose of the Study:
- To investigate the association between plasma vitamin D levels and Left Ventricular Ejection Fraction (LVEF) in patients admitted with their first acute Myocardial Infarction (MI).
Main Methods:
- A cross-sectional descriptive study involving 185 patients with a first acute MI was conducted.
- Plasma vitamin D levels were measured and categorized using a cut-off of 30 ng/ml, with further stratification into insufficiency, deficiency, and severe deficiency.
- Left Ventricular Ejection Fraction (LVEF) was assessed in all participants.
Main Results:
- A statistically significant inverse relationship was observed between plasma vitamin D levels and LVEF.
- Patients with normal vitamin D levels (>30 ng/ml) had a mean LVEF of 49.88±8.58%.
- LVEF progressively decreased with lower vitamin D levels: insufficiency (47.60±8.24%), deficiency (44.38±8.12%), and severe deficiency (<10 ng/ml) (40.61±8.64%).
Conclusions:
- Low plasma vitamin D levels are significantly associated with reduced Left Ventricular Ejection Fraction (LVEF) in patients hospitalized with their first acute Myocardial Infarction (MI).
- These findings suggest that maintaining adequate vitamin D status may be important for cardiac function recovery after acute MI.
Abstract:
It has been widely reported that vitamin D deficiency is associated with Coronary heart disease (CHD), especially acute Myocardial infarction (MI). Many factors are responsible for reduced Left ventricular ejection fraction (LVEF) and acute Left ventricular fraction (LVF) after acute MI. This cross sectional descriptive type of study was conducted in the Cardiology department of Mymensingh Medical College Hospital from October 2017 to March 2019 to investigate the relationship of plasma vitamin D with LVEF in patients with first attack of acute MI. Total 185 patients of first attack of acute MI were included considering inclusion and exclusion criteria. Fasting blood samples were analyzed for plasma vitamin D level. Sample population were grouped at first into two, normal and low vitamin D level, taking 30ng/ml as cut-off value, low vitamin D level is further subdivided into insufficiency (21-29ng/ml), deficiency (10-20ng/ml) and severe deficiency (<10ng/ml). LVEF among the patients was observed. LVEF was found 49.88±8.58% patients having normal vitamin D level (>30ng/ml), 47.60±8.24% of patients having vitamin D insufficiency (21-29ng/ml), 44.38±8.12% of patients having vitamin D deficiency (10-20ng/ml) and 40.61±8.64% patients having severe vitamin D deficiency (<10ng/ml), which was statistically significant (p<0.05). So, low plasma vitamin D level is associated with reduced LVEF in patients hospitalized with first attack of acute MI.
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