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Related Experiment Video

Updated: Dec 3, 2025

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
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Elevated Serum Tsukushi Levels in Patients With Hyperthyroidism.

Deying Liu1, Peizhen Zhang1, Xueyun Wei1

  • 1Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Frontiers in Endocrinology
|October 29, 2020
PubMed
Summary
This summary is machine-generated.

Circulating Tsukushi (TSK) levels are elevated in hyperthyroidism and decrease with treatment. TSK may serve as a predictive marker for hyperthyroidism and aid in monitoring treatment effectiveness.

Keywords:
Tsukushihepatokinehyperthyroidismmetabolismthyroid hormone

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Area of Science:

  • Endocrinology
  • Metabolic Research

Background:

  • Tsukushi (TSK) is a novel hepatokine involved in metabolic regulation.
  • The relationship between circulating TSK and human hyperthyroidism remains unexplored.

Purpose of the Study:

  • To investigate the association between serum TSK levels and hyperthyroidism.
  • To evaluate TSK as a potential biomarker for hyperthyroidism diagnosis and treatment monitoring.

Main Methods:

  • Serum TSK levels were measured in 180 hyperthyroid patients and 82 healthy controls.
  • TSK levels were assessed before and after 3 months of thionamide treatment in a subset of patients.
  • Statistical analyses, including multivariable regression, were used to determine associations.

Main Results:

  • Hyperthyroid patients exhibited significantly higher serum TSK levels compared to controls.
  • Serum TSK levels positively correlated with thyroid hormones (T3, T4) and negatively with treatment response.
  • TSK concentrations were independently associated with hyperthyroidism risk and various metabolic parameters.

Conclusions:

  • Circulating TSK is significantly elevated in hyperthyroidism and decreases with effective treatment.
  • TSK represents a potential independent predictive factor for hyperthyroidism.
  • TSK may be a valuable biomarker for therapeutic monitoring in hyperthyroid patients.