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Updated: Dec 3, 2025

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FGF18 Inhibits Clear Cell Renal Cell Carcinoma Proliferation and Invasion via Regulating Epithelial-Mesenchymal

Chen Yang1,2,3, Zheyu Zhang1,2, Fangdie Ye1,2

  • 1Department of Urology, Huashan Hospital, Fudan University, Shanghai, China.

Frontiers in Oncology
|October 29, 2020
PubMed

Insights

Fibroblast growth factor 18 (FGF18) is lowly expressed in clear cell renal cell carcinoma (ccRCC). Overexpressing FGF18 inhibits ccRCC progression and may serve as a therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Fibroblast growth factor 18 (FGF18) is implicated in various biological processes, including cancer progression.
  • Limited data exists on FGF18's role in clear cell renal cell carcinoma (ccRCC).

Purpose of the Study:

  • To investigate the biological functions and prognostic significance of FGF18 in ccRCC.
  • To explore FGF18's impact on ccRCC cell proliferation, epithelial-mesenchymal transition (EMT), and signaling pathways.

Main Methods:

  • Analysis of FGF18 expression in ccRCC tissues using TCGA and clinical cohorts.
  • In vitro and in vivo experiments to assess the effects of FGF18 overexpression on ccRCC cell lines.
  • Gene Set Enrichment Analysis (GSEA) to identify associated pathways.
  • Validation of EMT markers and PI3K/Akt pathway activity.

Main Results:

  • FGF18 expression was significantly lower in ccRCC tissues compared to normal renal tissues.
  • High FGF18 expression correlated with a better prognosis in ccRCC patients.
  • Overexpression of FGF18 suppressed ccRCC cell proliferation both in vitro and in vivo.
  • FGF18 overexpression was associated with reduced EMT and inhibited the PI3K/Akt pathway.

Conclusions:

  • FGF18 exhibits tumor-suppressive functions in ccRCC.
  • FGF18 may serve as a potential therapeutic target for ccRCC treatment.
Keywords:
FGF18clear cell renal cell carcinomaepithelial-mesenchymal transitioninvasionproliferation

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