Related Experiment Video

Updated: Dec 3, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.8K

Serum Elabela Level Significantly Increased in Patients with Complete Heart Block

Armağan Acele1, Atilla Bulut1, Yurdaer Donmez1

  • 1Adana Health Practice and Research Center University of Health Sciences Department of Cardiology Adana Turkey Department of Cardiology, University of Health Sciences - Adana Health Practice and Research Center, Adana, Turkey.

Brazilian Journal of Cardiovascular Surgery
|October 29, 2020
PubMed

Insights

Serum Elabela levels are significantly higher in patients with complete atrioventricular (AV) block. This new peptide may aid in the early detection of AV block, a condition often requiring pacemaker implantation.

Area of Science:

  • Cardiology
  • Biochemistry
  • Peptide Research

Background:

  • The apelinergic system plays a role in cardiovascular regulation.
  • Elabela is a newly identified peptide within the apelinergic system.
  • Complete atrioventricular (AV) block significantly impacts cardiac function and often necessitates pacemaker implantation.

Purpose of the Study:

  • To investigate serum Elabela levels in patients with complete AV block compared to healthy controls.
  • To explore the correlation of Elabela levels with cardiac function parameters and inflammatory markers.
  • To assess the diagnostic potential of Elabela for identifying complete AV block.

Main Methods:

  • Serum Elabela levels were measured in 50 patients with complete AV block scheduled for pacemaker implantation and 50 healthy controls.
  • Routine clinical data, physical examinations, and laboratory tests were collected.
  • Statistical analyses, including correlation and linear regression, were performed.

Main Results:

  • Patients with AV block exhibited significantly higher serum Elabela levels, lower heart rate, and reduced cardiac output compared to controls.
  • Serum Elabela levels correlated positively with high-sensitive C-reactive protein and NT-proBNP, and negatively with heart rate and cardiac output.
  • An Elabela level > 9.5 ng/ml demonstrated high sensitivity (90.2%) and specificity (88.0%) for detecting complete AV block.

Conclusions:

  • Serum Elabela levels are elevated in patients with complete AV block prior to pacemaker implantation.
  • Serum Elabela shows potential as a biomarker for the early determination of complete AV block.
  • Further research is warranted to elucidate the precise role of Elabela in AV block pathophysiology.
Abstract

Keywords:
Atrioventricular BlockC-Reactive ProteinCardiac OutputCholesterol, HDLPacemaker Artificial

More Related Videos

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction05:26

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

9.6K
Author Spotlight: Enhancing Graft Viability Assessment Through Quantitative Metrics and Innovative Reservoir Systems08:49

Author Spotlight: Enhancing Graft Viability Assessment Through Quantitative Metrics and Innovative Reservoir Systems

Published on: August 2, 2024

1.2K

Related Concept Videos

Dysrhythmias IV: Characteristics of Bradyarrhythmias01:18

Dysrhythmias IV: Characteristics of Bradyarrhythmias

Bradyarrhythmias are cardiac rhythm disorders characterized by a slower-than-normal heart rate, typically defined as fewer than 60 beats per minute. Some of which are discussed here:Sinus BradycardiaSinus bradycardia presents a heart rate lower than 60 beats per minute, with a regular rhythm originating from the SA node. The ECG typically shows normal P waves preceding each QRS complex, a normal PR interval (0.12 to 0.20 seconds), and a normal QRS duration (0.06 to 0.10 seconds).First-Degree AV...
343
Disturbances in Heart Rhythm01:29

Disturbances in Heart Rhythm

Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
2.1K
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
272
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
2.0K
Dysrhythmias V: Evaluating Dysrhythmias01:30

Dysrhythmias V: Evaluating Dysrhythmias

Dysrhythmias, also known as arrhythmias, are disturbances in the heart's rhythm that range from benign to life-threatening. A thorough evaluation is crucial for appropriate management and involves a comprehensive medical history, physical examination, and various diagnostic tests.Medical HistorySymptoms: Collect detailed information on palpitations, dizziness, syncope, chest pain, and fatigue. Note their onset, frequency, and triggers.Previous Cardiac Issues: Document any history of heart...
219
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
441