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Related Experiment Videos

Cocaine-Related Aortic Dissection: what do we know?

Dustin Greve1, Joana Funke1,2, Tiam Khairi1,2

  • 1Charité Universitätsmedizin Berlin Department of Cardiovascular Surgery Berlin Germany Department of Cardiovascular Surgery, Charité Universitätsmedizin Berlin, Berlin, Germany.

Brazilian Journal of Cardiovascular Surgery
|October 29, 2020
PubMed
Summary

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Cocaine use significantly increases the risk of aortic dissection, particularly in young males. This condition has a high mortality rate, underscoring the urgent need for awareness and intervention strategies.

Area of Science:

  • Cardiovascular Medicine
  • Toxicology
  • Vascular Surgery

Background:

  • Cocaine use is a known risk factor for vascular diseases.
  • Aortic dissection is a serious cardiovascular emergency.
  • The link between cocaine and aortic dissection requires further characterization.

Purpose of the Study:

  • To analyze the clinical features of cocaine-related aortic dissection.
  • To determine the outcomes of patients with cocaine-induced aortic dissection.
  • To compare outcomes with general aortic dissection patient cohorts.

Main Methods:

  • Retrospective analysis of 45 cases of cocaine-related aortic dissection.
  • Inclusion of 11 cases from an institutional database.
  • Inclusion of 34 published case reports.
Keywords:
AneurysmDissection. Cocaine-Related Disorders. Aortic AneurysmThoracic. Vascular Surgical Procedures. Treatment Outcome

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Main Results:

  • The cohort comprised predominantly young (mean age 41.3 years) and male (88.9%) patients.
  • Most cases (75%) were Stanford type A aortic dissections.
  • High in-hospital mortality (21.4%) and pre-hospital mortality (11.9%) were observed.

Conclusions:

  • Cocaine-related aortic dissection predominantly affects young males.
  • The outcomes for this patient group are significantly worse compared to general aortic dissection series.
  • This highlights the critical impact of cocaine on aortic health and patient prognosis.