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Related Concept Videos

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents01:18

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
Cholera01:25

Cholera

Cholera is an acute gastrointestinal disease caused by the Gram-negative bacterium Vibrio cholerae. It is transmitted primarily via the fecal-oral route through the ingestion of contaminated water or food.Vibrio cholerae is a motile, Gram-negative bacterium of the family Vibrionaceae, primarily associated with waterborne outbreaks in areas with inadequate sanitation. Although over 200 serogroups of V. cholerae exist, only O1 and O139 are responsible for epidemic cholera. The O1 serogroup,...
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Bacterial pathogens depend on precise and efficient DNA replication to sustain infection. Two type II topoisomerases—DNA gyrase and topoisomerase IV—are critical to this process, as they resolve DNA supercoiling and unlink chromosomes during replication. Fluoroquinolones, synthetic derivatives of quinolones, exploit this mechanism by stabilizing the transient DNA–enzyme cleavage complex, preventing strand religation, and causing lethal double-strand breaks. These antibiotics are selectively...

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Related Experiment Video

Updated: Jul 9, 2026

Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages
09:39

Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages

Published on: May 30, 2013

Single dose tetracycline in cholera.

M R Islam1

  • 1International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.

Gut
|August 1, 1987
PubMed
Summary
This summary is machine-generated.

Single-dose tetracycline (1g or 2g) effectively treats cholera by reducing stool volume and duration of illness. This antibiotic therapy offers a viable alternative to multiple doses, complementing rehydration efforts.

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Laboratory Techniques Used to Maintain and Differentiate Biotypes of Vibrio cholerae Clinical and Environmental Isolates
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Laboratory Techniques Used to Maintain and Differentiate Biotypes of Vibrio cholerae Clinical and Environmental Isolates
07:58

Laboratory Techniques Used to Maintain and Differentiate Biotypes of Vibrio cholerae Clinical and Environmental Isolates

Published on: May 30, 2017

Area of Science:

  • Infectious Diseases
  • Clinical Pharmacology
  • Tropical Medicine

Background:

  • Cholera remains a significant public health concern, necessitating effective and accessible treatment strategies.
  • Antibiotic therapy plays a crucial role in managing cholera by reducing fluid loss and shortening the duration of illness.
  • Optimizing antibiotic regimens for cholera, such as exploring single-dose options, can improve patient compliance and resource utilization.

Purpose of the Study:

  • To evaluate the efficacy of single-dose tetracycline regimens compared to multiple-dose and no-antibiotic treatments in adult cholera patients.
  • To assess the impact of different tetracycline dosages on clinical outcomes, including stool volume, duration of diarrhea, and Vibrio cholerae excretion.

Main Methods:

  • A randomized clinical trial involving 118 adult cholera patients.
  • Patients were assigned to four groups: single 1g tetracycline, single 2g tetracycline, multiple-dose tetracycline (500mg every 6 hours), and a control group (no antibiotics).
  • Outcomes measured included total liquid stool volume, duration of diarrhea, intravenous fluid requirements, and duration of Vibrio cholerae excretion.

Main Results:

  • All tetracycline treatment groups showed significantly lower total liquid stool volumes compared to the control group (p < 0.05).
  • Single-dose and multiple-dose tetracycline regimens significantly reduced the duration of diarrhea and intravenous fluid needs compared to controls (p < 0.05).
  • Tetracycline treatment significantly shortened the duration of Vibrio cholerae excretion, with the multiple-dose group showing the most pronounced effect (1.3 days).

Conclusions:

  • Single-dose tetracycline (1g or 2g) is a reasonable and effective alternative to multiple-dose therapy for cholera treatment, complementing rehydration.
  • While multiple-dose tetracycline remains the optimal choice, single-dose regimens offer a practical option with comparable efficacy in reducing key cholera symptoms.
  • Further research may explore the long-term implications and specific patient populations that benefit most from single-dose tetracycline therapy in cholera management.