SARS-CoV-2 vaccine candidates in rapid development

Area of Science:

• Virology
• Immunology
• Vaccinology

Background:

• The COVID-19 pandemic, caused by SARS-CoV-2, remains a global health crisis.
• Developing effective treatments and prevention strategies, particularly vaccines, is a priority.

Purpose of the Study:

• To review current knowledge on SARS-CoV-2.
• To provide updates on relevant animal models for COVID-19 research.
• To summarize the landscape of COVID-19 vaccines in clinical and preclinical development.

Main Methods:

• Literature review of scientific research on SARS-CoV-2.
• Analysis of vaccine development platforms and progress.
• Synthesis of data on vaccines in clinical and preclinical evaluation.

Main Results:

• Multiple vaccine development platforms are being utilized, including inactivated virus, DNA/RNA, viral vector, and subunit vaccines.
• There are 23 vaccines in clinical trials and over 140 candidates in preclinical stages.
• Research encompasses virus characteristics, animal models, and vaccine efficacy data.

Conclusions:

• COVID-19 vaccine development is progressing rapidly across various platforms.
• Continued investigation is crucial to ensure the safety and efficacy of emerging vaccines.
• The review highlights the dynamic state of vaccine research against SARS-CoV-2.