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Updated: Dec 3, 2025
07:35
Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
Published on: June 23, 2015
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Autosomal Dominant Polycystic Kidney Disease
Parvathi Perumareddi1, Darin P Trelka1
1Florida Atlantic University, Schmidt College of Medicine, 777 Glades Road, Boca Raton, FL 33431, USA.
Primary Care
|October 30, 2020
Summary
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is an inherited kidney disorder causing cysts and kidney enlargement. Early risk factor modification is crucial as there is no cure, with renal transplant being the optimal treatment for end-stage renal disease.
Area of Science:
- Nephrology
- Genetics
- Internal Medicine
Background:
- Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic, multisystemic disorder.
- It is characterized by renal tubule cyst formation and kidney enlargement.
- ADPKD affects multiple organs and can lead to secondary hypertension and other complications.
Purpose of the Study:
- To summarize the key aspects of Autosomal Dominant Polycystic Kidney Disease.
- To highlight diagnostic considerations and associated conditions.
- To emphasize the importance of early intervention and management strategies.
Main Methods:
- Review of existing literature on Autosomal Dominant Polycystic Kidney Disease.
- Synthesis of diagnostic criteria and clinical manifestations.
- Analysis of disease progression and treatment options.
Main Results:
- Diagnosis is often suspected based on family history, early-onset hypertension, or specific symptoms.
- Renal function is typically preserved for years due to compensatory mechanisms.
- Associated conditions include liver cysts, berry aneurysms, and kidney stones.
Conclusions:
- ADPKD is a progressive disease, often leading to end-stage renal failure by age 60.
- There is currently no cure for ADPKD.
- Risk factor modification in early stages and renal transplant for ESRD are critical management strategies.
Keywords:
Berry aneurysmDialysisEnd-stage renal diseaseHematuriaLiver cystsPolycystic kidney diseaseSecondary hypertensionTransplantMore Related Videos
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