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Biologic Therapy for Ulcerative Colitis

Abhik Bhattacharya1, Mark Tomislav Osterman2

  • 1Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital, 1468 Madison Avenue, Annenberg Building, 5th floor, Room A5-07C, New York City, NY 11101, USA. Electronic address: https://twitter.com/abhikbhatta.

Gastroenterology Clinics of North America
|October 30, 2020
PubMed

Five biologics are approved for the treatment of ulcerative colitis (UC): infliximab, adalimumab, golimumab, vedolizumab, and ustekinumab. These drugs have varying levels of efficacy and are recommended as first-line treatment of moderate to severe UC. There has been only 1 head-to-head trial comparing the efficacy of the biologics, adalimumab and vedolizumab, which has important implications for management. Therapeutic drug monitoring of biologics, especially anti-TNF alpha agents, may improve the long-term efficacy of these agents. The future of treatment may include personalization of medications, based on patient-specific and disease-specific characteristics as well as biomarkers, along with appropriate therapeutic drug monitoring.

Keywords:
BiologicsTherapeutic drug monitoringUlcerative colitis

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