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Harpagide: Occurrence in plants and biological activities - A review
Claudio Frezza1, Daniela de Vita1, Chiara Toniolo1
1Dipartimento di Biologia Ambientale, Università di Roma "La Sapienza", Piazzale Aldo Moro 5, 00185 Rome, Italy.
Abstract:
In this review article, the occurrence of harpagide in the plant kingdom and its associated biological activities are presented and detailed for the first time. The presence of harpagide has been reported in several botanical families within Asteridae, and harpagide has been observed to exert a wide number of biological activities such as cytotoxic, anti-inflammatory, and neuroprotective. These results show how harpagide can be recovered from several natural sources for several pharmacological purposes even if there is a lot to still be studied. Nowadays, the interest is related to its presence in phytomedicines. Threfore, these studies are useful to support and validate the large use of several plants in the folklore medicine.
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