Related Experiment Video

Updated: Dec 3, 2025

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis
04:36

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis

Published on: October 2, 2020

2.5K

Temporal changes in complement activation in haemodialysis patients with COVID-19 as a predictor of disease

Maria Prendecki1, Candice Clarke1, Nicholas Medjeral-Thomas1

  • 1Centre for Inflammatory Disease, Imperial College London, London, UK.

Clinical Kidney Journal
|October 30, 2020
PubMed

Insights

Complement activation is implicated in severe COVID-19 pathogenesis. Elevated C5a and C3a levels were observed in hemodialysis patients, with C5a potentially indicating earlier disease severity.

Area of Science:

  • Immunology
  • Virology
  • Nephrology

Background:

  • Severe COVID-19 is linked to complement activation, potentially causing inflammation and microvascular thrombosis.
  • Complement system activation may contribute to organ damage in severe COVID-19.

Purpose of the Study:

  • To investigate the role of complement activation in severe COVID-19 patients undergoing maintenance hemodialysis.
  • To assess plasma levels of C3a and C5a as potential biomarkers for COVID-19 severity.

Main Methods:

  • Plasma samples were collected from hemodialysis patients with and without COVID-19.
  • Enzyme-linked immunosorbent assay was used to measure plasma C3a and C5a levels.

Main Results:

  • Hemodialysis patients with severe COVID-19 exhibited elevated plasma C3a and C5a levels compared to controls.
  • Elevated C5a levels preceded clinical deterioration in patients who developed severe COVID-19.
  • C3a levels correlated more closely with clinical and biochemical markers of disease severity.

Conclusions:

  • Complement activation contributes to COVID-19 pathogenesis, causing endothelial injury and lung damage.
  • C5a may serve as an earlier biomarker for COVID-19 severity than C-reactive protein.
  • Complement inhibition is a potential therapeutic strategy for severe COVID-19.
Abstract

Keywords:
COVID-19complementhaemodialysis

More Related Videos

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells06:29

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

31.0K
Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-1908:48

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Published on: February 16, 2022

3.2K

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
389
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
170
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
516
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
607
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
383
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
340