Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

1.7K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
1.7K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

1.0K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
1.0K
Disorders of Leukocytes01:27

Disorders of Leukocytes

1.6K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
1.6K
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

8.4K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
8.4K
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

589
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
589
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

13.7K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
13.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Scholar 12 longitudinal outcomes: osteopathic research development application to facilitate scholarly activity during the pandemic and beyond.

Journal of osteopathic medicine·2025
Same author

The effect of osteopathic manipulative treatment on chronic rhinosinusitis.

Journal of osteopathic medicine·2025
Same author

Novel BTK Mutation in Patient with Late Diagnosis of X-Linked Agammaglobulinemia.

Case reports in immunology·2023
Same author

Augmentation of immune response to vaccinations through osteopathic manipulative treatment: a study of procedure.

Journal of osteopathic medicine·2023
Same author

A patient with a corticosteroid-resistant pruritic rash.

International journal of dermatology·2022
Same author

COVID-19 Infection in Patients with Humoral Immunodeficiency: A Case Series and Literature Review.

Allergy & rhinology (Providence, R.I.)·2022

Related Experiment Video

Updated: Dec 3, 2025

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.0K

Posner-Schlossman Syndrome in Common Variable Immunodeficiency.

Madiha Huq1, Neha Sanan2, Phuong Daniels3

  • 1University Hospitals Parma Medical Center, Cleveland, Ohio, USA.

Case Reports in Ophthalmological Medicine
|October 30, 2020
PubMed
Summary

This case report details the first instance of Posner-Schlossman syndrome (PSS), a rare glaucoma, occurring in a patient with common variable immunodeficiency (CVID). This finding suggests a potential link between PSS and autoimmune disorders like CVID.

More Related Videos

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

653
Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients
05:26

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients

Published on: March 1, 2024

1.6K

Related Experiment Videos

Last Updated: Dec 3, 2025

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.0K
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

653
Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients
05:26

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients

Published on: March 1, 2024

1.6K

Area of Science:

  • Ophthalmology
  • Immunology

Background:

  • Posner-Schlossman syndrome (PSS) is a rare condition characterized by recurrent episodes of unilateral elevated intraocular pressure.
  • The etiology of PSS is uncertain, with proposed links to autoimmune and infectious causes.
  • Common variable immunodeficiency (CVID) is an autoimmune disorder associated with various systemic and ocular conditions.

Observation:

  • A 62-year-old female with a history of CVID and ulcerative colitis presented with acute vision changes in her right eye.
  • Initial examination revealed elevated intraocular pressure (IOP) of 34 mmHg in the right eye and decreased visual acuity.
  • Despite initial IOP-lowering treatment, subsequent examination showed anterior uveitis and significantly elevated IOP (41 mmHg) in the right eye, confirming a PSS diagnosis.

Findings:

  • This report documents the first case of PSS diagnosed in a patient with known common variable immunodeficiency (CVID).
  • The patient presented with classic symptoms of PSS, including unilateral elevated IOP and anterior uveitis.
  • The co-occurrence suggests a potential association between PSS and autoimmune conditions like CVID.

Implications:

  • This case expands the known spectrum of ocular manifestations associated with CVID.
  • It highlights the importance of considering PSS in patients with CVID who present with glaucomatocyclitic crises.
  • Further research may elucidate the underlying mechanisms linking CVID and PSS, potentially improving diagnostic and therapeutic strategies.