Related Experiment Video
Updated: Dec 3, 2025
09:20
Intradermal Inoculation of Mycobacterium avium in the Mouse Ear
Published on: July 3, 2025
921
Subtle immunodeficiencies in nodular-bronchiectatic Mycobacterium avium complex lung disease
Mariolina Bruno1, Sanne M H Zweijpfenning2, Jeske Verhoeven2
1Dept of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
ERJ Open Research
|October 30, 2020
Summary
Patients with MAC lung disease show immune system imbalances, including low IL-17 and IFN-γ and high IL-10. These findings support exploring new treatments that modify the immune response.
Area of Science:
- Immunology
- Pulmonology
- Microbiology
Background:
- Nodular-bronchiectatic Mycobacterium avium complex (MAC) lung disease is a chronic infection.
- Adaptive immunity plays a crucial role in controlling MAC lung disease.
- Immune dysregulation is implicated in the pathogenesis of MAC lung disease.
Purpose of the Study:
- To investigate the adaptive immune response in patients with nodular-bronchiectatic MAC lung disease.
- To characterize the production of key cytokines, including IL-17, IFN-γ, and IL-10, in these patients.
Main Methods:
- Analysis of cytokine profiles in patients with nodular-bronchiectatic MAC lung disease.
- Assessment of adaptive immune cell function.
Main Results:
- Patients exhibited defective production of Interleukin-17 (IL-17) and Interferon-gamma (IFN-γ).
- A significant overproduction of Interleukin-10 (IL-10) was observed.
- These cytokine imbalances indicate a dysregulated adaptive immune response.
Conclusions:
- The findings highlight a specific pattern of immune dysregulation in nodular-bronchiectatic MAC lung disease.
- The defective IL-17 and IFN-γ production, coupled with IL-10 overproduction, suggests a potential role for immunomodulatory therapies.
- Targeting these immune pathways may offer novel adjunctive treatment strategies for MAC lung disease.
Related Concept Videos
01:31Pulmonary Tuberculosis III
669
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
669
01:28Pulmonary Tuberculosis II
1.0K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
1.0K
01:29Pulmonary Tuberculosis I
574
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
574
01:25Immunodeficiency Diseases
1.7K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
1.7K
01:28Pulmonary Tuberculosis V
349
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
349
01:26Pulmonary Tuberculosis IV
309
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
309