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Updated: Dec 3, 2025
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Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
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Roles of Non-Coding RNAs on Anaplastic Thyroid Carcinomas
Plabon Kumar Das1, Saharia Yeasmin Asha1, Ichiro Abe2,3
1Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh.
Cancers
|October 31, 2020
Summary
Anaplastic thyroid cancer (ATC) is aggressive, but non-coding RNAs like miRNAs and lncRNAs show abnormal expression. Targeting these RNAs offers potential new therapies and prognostic biomarkers for ATC patients.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Anaplastic thyroid cancer (ATC) is a highly aggressive carcinoma with poor patient survival rates.
- Current therapeutic interventions for ATC have limited efficacy.
- Novel targeted and personalized therapies are needed to improve outcomes for ATC patients.
Purpose of the Study:
- To review the role of non-coding RNAs in gene expression regulation in ATC.
- To explore how altered non-coding RNA expression impacts ATC characteristics.
- To identify non-coding RNAs as potential therapeutic targets and prognostic biomarkers for ATC.
Main Methods:
- Review of scientific literature on non-coding RNAs in anaplastic thyroid cancer.
- Analysis of dysregulated microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in ATC tissues and cells.
- Investigation of the regulatory mechanisms of non-coding RNAs in oncogene modulation during tumor progression.
Main Results:
- Numerous miRNAs (e.g., miR-205, miR-19a, miR-155) and lncRNAs (e.g., H19, HCP5, UCA1, NEAT1) exhibit abnormal expression in ATC.
- These non-coding RNAs are involved in transcriptional and post-transcriptional gene regulation in ATC.
- Dysregulation of non-coding RNAs is linked to ATC development and progression by affecting oncogene functions.
Conclusions:
- Restoring abnormal miRNA and lncRNA expression presents a promising therapeutic strategy for ATC.
- Non-coding RNAs can serve as valuable prognostic biomarkers for better ATC patient management.
- siRNA-mediated inhibition of oncogenes is another potential therapeutic avenue for ATC.
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