Omics in Myopia.

Area of Science:

• Ophthalmology
• Biochemistry
• Genetics

Background:

• Myopia is a significant global health issue with considerable medical and socioeconomic impacts.
• Current treatments for myopia are limited, highlighting the need for deeper understanding of its pathogenesis.
• Altered biochemical pathways are implicated in myopia development, necessitating further investigation.

Purpose of the Study:

• To review current data on metabolomics and proteomics in human myopia.
• To present and evaluate various experimental approaches and animal models for myopia research.
• To discuss the clinical applicability of findings and suggest future research directions.

Main Methods:

• Comprehensive literature review of metabolomic and proteomic studies in myopia.
• Analysis of experimental methodologies and animal models used in myopia research.
• Synthesis of findings related to biochemical alterations in myopia.

Main Results:

• Myopia is associated with specific alterations in metabolic and protein profiles.
• Various experimental models offer insights but have limitations.
• Understanding these biochemical changes is crucial for developing new strategies.

Conclusions:

• Metabolomics and proteomics offer promising avenues for understanding myopia pathogenesis.
• Further research integrating these 'omics' approaches is needed for clinical translation.
• This review provides a foundation for developing novel diagnostic and therapeutic interventions for myopia.