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NORAD, a critical long non-coding RNA in human cancers
Negin Soghli1, Tooba Yousefi2, Maryam Abolghasemi2
1Student Research Committee, Babol University of Medical Sciences, Babol, Iran; Dental Faculty, Babol University of Medical Sciences, Babol, Iran.
Life Sciences
|October 31, 2020
Summary
Cancer incidence is rising globally. This review explores the role of Non-coding RNA activated by DNA damage (NORAD) in cancer, highlighting its functions in genome stability and tumorigenesis.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Cancer is a growing global health concern, becoming a leading cause of death.
- Long non-coding RNAs (lncRNAs) are key regulators of gene expression.
- Non-coding RNA activated by DNA damage (NORAD) is crucial for maintaining genome stability.
Purpose of the Study:
- To review the role and biological functions of lncRNA NORAD in human cancers.
- To provide insights for future research on NORAD in cancer biology.
Main Methods:
- Literature review of studies on lncRNA NORAD and cancer.
- Analysis of NORAD's involvement in carcinogenic processes.
Main Results:
- LncRNA NORAD is frequently dysregulated in various human cancers.
- NORAD influences key cancer hallmarks including proliferation, apoptosis, invasion, and metastasis.
- NORAD's role in genome stability is linked to its oncogenic functions.
Conclusions:
- LncRNA NORAD is a significant player in cancer development and progression.
- NORAD's dysregulation presents potential as a biomarker for various cancers.
- Further research into NORAD's mechanisms can inform cancer diagnostics and therapeutics.
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