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Radiosensitization by Au-nanofilm at micrometer level using confocal Raman spectroscopy
Rodrigo Hernández Millares1, Jamal Ahmad Mirza1,2, Junyoung Lee1
1Program in Biomedical Radiation Sciences, Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, Korea.
Medical Physics
|October 31, 2020
Summary
Gold nanofilms (GNF) enhance radiation dose deposition on radiochromic films (RCF) at the micrometer level. Confocal Raman spectroscopy (CRS) measured a dose enhancement factor (DEF) up to 17.9, validating CRS-RCF as a micrometer-resolution dosimeter.
Area of Science:
- Medical Physics
- Nanotechnology
- Spectroscopy
Background:
- Radiochromic films (RCF) are widely used for radiation dosimetry.
- Gold nanofilms (GNF) offer potential for enhancing radiation dose deposition.
- Confocal Raman spectroscopy (CRS) provides high spatial resolution for material analysis.
Purpose of the Study:
- To measure the radiosensitization effect of gold nanofilms (GNF) on radiochromic films (RCF) at the micrometer level.
- To evaluate the dose enhancement factor (DEF) using confocal Raman spectroscopy (CRS).
- To validate experimental findings with Monte Carlo (MC) simulations and analytical calculations.
Main Methods:
- RCFs were irradiated with X-rays to establish a calibration curve.
- CRS was employed to obtain depth profiles of irradiated RCFs.
- The spatial resolution of CRS was determined using the modulation transfer function (MTF) method.
- DEF was calculated by comparing doses on RCFs with and without GNF.
- MC simulations (Geant4) and analytical calculations were performed for verification.
Main Results:
- CRS achieved a spatial resolution of approximately 6 μm on RCF.
- Experimental DEF values were 17.9 (50 kVp) and 14.7 (120 kVp) within the first 6 μm.
- MC simulations yielded DEF values of 13.53 (50 kVp) and 10.63 (120 kVp).
- Analytical calculations showed DEF values of 9.75 (50 kVp) and 6.67 (120 kVp).
Conclusions:
- Experimental DEF measurements are consistent with MC simulations and prior studies.
- CRS coupled with RCF serves as a viable dosimeter with micrometer resolution.
- This technique enables precise measurement of radiosensitization effects at the microscale.
