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Sulpiride intoxication: Case report of a rare intoxication
Svenja Zonneveld1, Adina Gawi2, Erik B Wilms3
1Department of clinical pharmacy, Haaglanden Medical Centre, The Hague, The Netherlands.
Basic & Clinical Pharmacology & Toxicology
|October 31, 2020
Summary
This case study details the successful management of a rare sulpiride intoxication, an antipsychotic drug. Prompt diagnosis and supportive care, including activated charcoal and sodium bicarbonate, led to patient recovery.
Area of Science:
- Pharmacology
- Toxicology
- Emergency Medicine
Background:
- Sulpiride intoxication is uncommon, with limited documented cases and treatment guidelines.
- Antipsychotic drug overdoses present significant clinical challenges in emergency settings.
Observation:
- A 67-year-old female presented with hemodynamic instability and decreased consciousness following a suspected suicide attempt.
- Initial assessment revealed a Glasgow Coma Scale of 3 and QTc interval prolongation.
- Toxicology screening confirmed sulpiride overdose, prompting intensive care unit admission.
Findings:
- The patient received supportive care including intubation, activated charcoal, laxatives, and sodium bicarbonate.
- Hemodynamic stability and ECG normalized within 24 hours, allowing for extubation.
- Treatment focused on symptomatic management and avoiding specific antiarrhythmic drugs that could exacerbate hypotension.
Implications:
- This case highlights the importance of rapid diagnosis and multidisciplinary consultation in managing rare drug intoxications.
- Effective supportive care can lead to favorable outcomes in severe sulpiride overdose.
- Clinicians should be aware of the potential for QTc prolongation and hemodynamic compromise in sulpiride toxicity.
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