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A multiple therapy hypothesis for treatment of COVID-19 patients
1U.S. Department of Agriculture, Agricultural Research Service, Chemical Residue and Predictive Microbiology Research Unit, Room 2111, Center for Food Science and Technology, University of Maryland Eastern Shore, Princess Anne, MD 21853, United States.
Abstract:
The coronavirus disease 2019 (COVID-19) pandemic, which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has killed more than one million people as of October 1, 2020. Consequently, a search is on for a treatment that can bring the pandemic to an end. However, treatments (vaccine, antiviral, plasma) that are directed at specific viral proteins (RNA polymerase, spike proteins) may not work well against all strains of the virus. Therefore, it is hypothesized that a therapy based on multiple treatments is needed for COVID-19 patients and to bring the pandemic to an end. Here, it is proposed that a combination of cool air therapy (CAT) and purified air technology (PAT) in an oxygen species cool air respirator (OSCAR) could be used to reduce viral (SARS-CoV-2) load and severity of illness in COVID-19 patients through the individual dose-response relationship. In addition, the proposed therapy (CAT + PAT in OSCAR), which works by a more general physical and chemical mechanism, should work well with other treatments (vaccine, antiviral, plasma) that target specific viral proteins (RNA polymerase, spike proteins) to provide a safe and effective multiple therapy approach for ending the COVID-19 pandemic caused by SARS-CoV-2.
Insights
A novel cool air therapy combined with purified air technology may reduce SARS-CoV-2 viral load and illness severity in COVID-19 patients. This physical and chemical approach complements existing treatments for a comprehensive pandemic solution.
Area of Science:
- Respiratory medicine
- Infectious diseases
- Biotechnology
Background:
- COVID-19 pandemic caused by SARS-CoV-2 has led to significant mortality.
- Current treatments targeting specific viral proteins may face challenges with evolving strains.
- A multi-faceted therapeutic strategy is crucial for managing the pandemic.
Purpose of the Study:
- To propose a novel combination therapy for COVID-19.
- To investigate the potential of cool air therapy (CAT) and purified air technology (PAT) in an oxygen species cool air respirator (OSCAR).
- To reduce viral load and illness severity in COVID-19 patients.
Main Methods:
- The proposed therapy involves a combination of CAT and PAT delivered via OSCAR.
- This approach utilizes a general physical and chemical mechanism.
- Individual dose-response relationships are considered for personalized treatment.
Main Results:
- The CAT + PAT in OSCAR therapy is hypothesized to reduce SARS-CoV-2 viral load.
- The proposed method is expected to decrease the severity of illness in COVID-19 patients.
- This therapy is anticipated to work synergistically with existing treatments like vaccines and antivirals.
Conclusions:
- A combination of CAT and PAT in OSCAR offers a promising physical and chemical therapeutic approach for COVID-19.
- This novel therapy could serve as a safe and effective adjunct to treatments targeting specific viral proteins.
- The proposed multi-therapy strategy holds potential for controlling the COVID-19 pandemic.
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