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Updated: Dec 2, 2025

A High-Yield Streptomyces Transcription-Translation Toolkit for Synthetic Biology and Natural Product Applications
Published on: September 10, 2021
Synthetic biology for natural product drug production and engineering
Sean Romanowski1, Alessandra S Eustáquio1
1Department of Pharmaceutical Sciences, and Center for Biomolecular Sciences, College of Pharmacy, University of Illinois at Chicago, IL, USA.
Abstract:
Natural products continue to provide privileged scaffolds for drug discovery. However, challenges in supply and structure diversification can limit development. Here, we discuss recent (2017-2020) examples of synthetic biology approaches used to address challenges in supply and contribute to structure diversification of selected plant and bacterial natural products. Our examples include plant terpenoids, alkaloids, and lignans and bacterial polyketides, nonribosomal peptides, and ribosomally synthesized and posttranslationally modified peptides.
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