Related Experiment Video
Updated: Dec 2, 2025

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
Published on: August 9, 2012
URODYNAMIC PATTERNS OF ARTIFICIAL BLADDER
R Savchuk1, F Kostyev1, Y Dekhtiar1
1Odessa National Medical University, Ukraine.
Radical cystectomy with ileal neobladder creation is standard for muscle-invasive bladder cancer. Urodynamic studies reveal unique features, including potential atony and incontinence, requiring further investigation for improved patient outcomes.
Area of Science:
- Urology
- Oncology
- Surgical Innovation
Background:
- Muscle-invasive bladder cancer necessitates radical cystectomy.
- Ileal neobladder creation is a preferred method for urinary diversion, aiming to restore transurethral urination.
- Understanding the urodynamic characteristics of neobladders is crucial for optimizing patient function.
Purpose of the Study:
- To investigate the urodynamic features of artificial bladders created from the ileum following radical cystoprostatectomy.
- To identify potential complications and functional deficits associated with ileal neobladders.
Main Methods:
- A study group of 57 patients with invasive bladder cancer who underwent radical cystoprostatectomy with ileocystoplasty.
- Urodynamic evaluation of the created artificial bladders.
- Assessment of urinary incontinence and voiding difficulties.
Main Results:
- Artificial bladders derived from the ileum exhibit distinct urodynamic results compared to native bladder pathologies.
- Severe atony of the neobladder was observed in some patients, leading to chronic urinary insufficiency and obstruction.
- Urinary incontinence, both day and night, was reported by some patients, with some showing a lack of neobladder overactivity.
Conclusions:
- Ileal neobladders present unique urodynamic profiles that differ significantly from native bladder conditions.
- Neobladder atony and potential overactivity are significant factors contributing to urinary insufficiency and incontinence.
- Further research into the pathogenetic features and correction methods for neobladder dysfunction is warranted.
Related Concept Videos
Urodynamic Studies: Uroflowmetry
Urinary Bladder
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
The Micturition Reflex
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
Anatomy of the Genitourinary System II: Bladder and Urethra
Imaging Studies VI: Voiding Cystourethrography and Cystography
Imaging Studies II: Ultrasonography

