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Updated: Dec 2, 2025
09:09
A Murine Model of Cervical Spinal Cord Injury to Study Post-lesional Respiratory Neuroplasticity
Published on: May 28, 2014
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Noninvasive Ventilation and Spinal Cord Injury
Asil Daoud1, Samran Haider1, Abdulghani Sankari2
1Department of Medicine, John D. Dingell VA Medical Center, Wayne State University, Detroit Medical Center, 3990 John R St, Detroit, MI 48201, USA; Department of Medicine, Wayne State University, Detroit, MI, USA; Detroit Medical Center, Detroit, MI, USA.
Sleep Medicine Clinics
|November 2, 2020
Summary
Individuals with spinal cord injury (SCI) face higher risks of breathing issues during sleep. Management of sleep-disordered breathing (SDB) in SCI requires personalized strategies, with noninvasive ventilation showing potential but facing adherence challenges.
Area of Science:
- Neurology
- Pulmonology
- Sleep Medicine
Background:
- Spinal cord injury (SCI) significantly increases the risk of respiratory complications.
- Sleep-disordered breathing (SDB) is a common comorbidity in SCI patients.
- Respiratory control dysfunction is a key factor in SDB pathogenesis, particularly in cervical SCI.
Purpose of the Study:
- To review the role of respiratory control in SDB in SCI.
- To discuss the application of noninvasive ventilation in managing SCI-related respiratory complications.
- To evaluate the efficacy and long-term outcomes of positive airway pressure (PAP) treatment for SDB in SCI.
Main Methods:
- Literature review focusing on SDB in SCI.
- Analysis of respiratory control mechanisms in SCI.
- Evaluation of noninvasive ventilation strategies, including PAP therapy.
Main Results:
- SDB is prevalent in SCI, linked to impaired respiratory control.
- Noninvasive ventilation is crucial for managing acute and chronic respiratory issues in SCI.
- PAP therapy can improve SDB and sleepiness, but adherence is a significant barrier, and long-term benefits remain uncertain.
Conclusions:
- Individualized management is essential for SDB in SCI.
- Noninvasive ventilation is a key therapeutic option, though long-term efficacy requires further investigation.
- Addressing adherence issues is critical for optimizing treatment outcomes in SCI patients with SDB.
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