Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

853
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
853
Antibiotic Selection00:57

Antibiotic Selection

58.1K
Overview
58.1K
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

6.1K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
6.1K
Allergic Reactions02:06

Allergic Reactions

30.7K
Overview
30.7K
Factors Affecting Protein-Drug Binding: Drug-Related Factors01:18

Factors Affecting Protein-Drug Binding: Drug-Related Factors

342
Drug binding to proteins is a complex phenomenon influenced by various drug-related factors, each playing a significant role in the interaction between drugs and proteins within the body.
One crucial factor in drug-protein binding is the drug's lipophilicity or its affinity for fat. More lipophilic drugs tend to have higher binding extents. For example, highly lipophilic drugs like cloxacillin exhibit substantial protein binding, with as much as 95% of the drug binding to proteins. In...
342
Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

90
Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
90

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of Tdap vaccine immunogenicity between pregnant and non-pregnant active duty service members.

Vaccine·2026
Same author

Influenza vaccine response is predicted by chronotype and differentially associated with pre- and post-vaccination sleep.

Brain, behavior, & immunity - health·2026
Same author

Incriminating the inotrope: Dobutamine, eosinophilia, and myocarditis.

The journal of allergy and clinical immunology. Global·2026
Same author

SARS-CoV-2 infection and sleep health in Military Health System beneficiaries.

Sleep advances : a journal of the Sleep Research Society·2026
Same author

A randomized clinical trial of the impact of melatonin on influenza vaccine: Outcomes from the melatonin and vaccine response immunity and chronobiology study (MAVRICS).

Human vaccines & immunotherapeutics·2024
Same author

Navigating the management complexity in long-term asymptomatic immunodeficiency.

Allergy and asthma proceedings·2023
Same journal

A Case Report of Unanticipated Difficult Intubation Due to Posterior Tracheal Angulation.

Federal practitioner : for the health care professionals of the VA, DoD, and PHS·2026
Same journal

Factors Influencing Outcomes of a Telehealth-Based Physical Activity Program in Older Veterans Postdischarge.

Federal practitioner : for the health care professionals of the VA, DoD, and PHS·2026
Same journal

Updates in Multiple Sclerosis Imaging.

Federal practitioner : for the health care professionals of the VA, DoD, and PHS·2026
Same journal

Impact of Retroactive Application of Updated Surveillance Guidelines on Endoscopy Center Capacity at a Large VA Health Care System.

Federal practitioner : for the health care professionals of the VA, DoD, and PHS·2026
Same journal

The Integration of Extended Reality in Arthroplasty: Reviewing Technological Progress and Clinical Benefits.

Federal practitioner : for the health care professionals of the VA, DoD, and PHS·2026
Same journal

American Hunger Games: Food Insecurity Among the Military and Veterans.

Federal practitioner : for the health care professionals of the VA, DoD, and PHS·2026
See all related articles

Related Experiment Video

Updated: Dec 2, 2025

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
11:15

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

Published on: July 24, 2021

5.2K

Penicillin Allergy Delabeling Can Decrease Antibiotic Resistance, Reduce Costs, and Optimize Patient Outcomes.

Rachel U Lee1

  • 1is a Staff Allergist and Immunologist in the Division of Allergy, Department of Internal Medicine at the Naval Medical Center in San Diego, California.

Federal Practitioner : for the Health Care Professionals of the VA, Dod, and PHS
|November 2, 2020
PubMed
Summary
This summary is machine-generated.

Over 90% of patients with a penicillin allergy label are not truly allergic. Evaluating and removing this label improves patient outcomes, reduces healthcare costs, and enhances military readiness by ensuring optimal antibiotic use.

More Related Videos

Antibiotic Dereplication Using the Antibiotic Resistance Platform
10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

11.3K
Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

13.2K

Related Experiment Videos

Last Updated: Dec 2, 2025

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
11:15

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

Published on: July 24, 2021

5.2K
Antibiotic Dereplication Using the Antibiotic Resistance Platform
10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

11.3K
Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

13.2K

Area of Science:

  • Infectious Diseases
  • Allergy and Immunology
  • Pharmacology

Background:

  • Penicillins are widely prescribed antibiotics due to efficacy and cost-effectiveness.
  • Penicillin allergy is the most common drug allergy listed, affecting 8-15% of patients.
  • Over 90% of patients labeled with penicillin allergy are not truly allergic.

Purpose of the Study:

  • To highlight the clinical, public health, and economic consequences of inaccurate penicillin allergy labels.
  • To emphasize the benefits of penicillin allergy evaluation and delabeling, particularly in military settings.

Main Methods:

  • Review of evidence regarding penicillin allergy prevalence and implications.
  • Analysis of healthcare costs and adverse effects associated with avoiding penicillins.
  • Consideration of military readiness and infection risks in personnel.

Main Results:

  • Inaccurate penicillin allergy labels lead to avoidance of essential beta-lactam antibiotics.
  • This avoidance increases healthcare costs, hospitalization duration, and adverse events.
  • Military personnel face higher infection risks, making accurate antibiotic availability crucial.

Conclusions:

  • Penicillin allergy delabeling improves clinical outcomes and reduces adverse events.
  • It prevents the spread of antibiotic resistance by enabling appropriate antibiotic selection.
  • For military personnel, delabeling enhances readiness and expedites return to full duty.