Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Female Reproductive System01:24

Disorders of the Female Reproductive System

3.7K
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
3.7K
Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

1.5K
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
1.5K
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

526
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
526
Menses Phase01:18

Menses Phase

805
The uterine cycle begins with the menstrual phase, which is considered day one of the cycle and typically lasts about five days. This phase is characterized by the degeneration and shedding of the stratum functionalis, the functional layer of the endometrium.
When fertilization does not occur, the corpus luteum deteriorates, causing a significant drop in the levels of estrogen and progesterone in the body. This hormonal decrease triggers the release of prostaglandins, which cause the uterine...
805
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

380
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
380
Oogenesis02:07

Oogenesis

68.0K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
68.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genitourinary microbiota in older women: a persistent knowledge gap that limits clinical and research progress.

Infection and immunity·2026
Same author

Bortezomib-induced gastrointestinal dysfunction, peripheral neuropathy and neuroimmune signalling are influenced by the gut microbiota in mice.

Journal of neuroinflammation·2026
Same author

Different types of sensory nerve endings in the urinary bladder of mice arising from dorsal root ganglia (DRG) at the thoracolumbar region of vertebral column.

Cell and tissue research·2026
Same author

Fundamentals of Neurogastroenterology: Basic Science.

Gastroenterology·2026
Same author

Parasites trigger epithelial cell crosstalk to drive gut-brain signalling.

Nature·2026
Same author

Circular economy: water quality assessment for irrigation purposes in a constructed-wetland scenario.

Scientific reports·2026

Related Experiment Video

Updated: Dec 2, 2025

Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity
07:20

Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity

Published on: December 21, 2012

16.3K

Pain in Endometriosis.

Jessica Maddern1,2, Luke Grundy1,2, Joel Castro1,2

  • 1Visceral Pain Research Group, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Adelaide, SA, Australia.

Frontiers in Cellular Neuroscience
|November 2, 2020
PubMed
Summary

Endometriosis pain mechanisms are poorly understood. This review covers inflammation, nerve pathways, and cross-organ sensitization contributing to chronic pelvic pain and co-morbidities in women with endometriosis.

Keywords:
chronic pelvic painhyperalgesiainflammationneuroangiogenesisperipheral sensitizationsensory afferentsuterusvagina

More Related Videos

Ex Vivo Method for Assessing the Mouse Reproductive Tract Spontaneous Motility and a MATLAB-based Uterus Motion Tracking Algorithm for Data Analysis
06:22

Ex Vivo Method for Assessing the Mouse Reproductive Tract Spontaneous Motility and a MATLAB-based Uterus Motion Tracking Algorithm for Data Analysis

Published on: September 1, 2019

9.4K
Surgical Techniques to Optimize Ovarian Reserve during Laparoscopic Cystectomy for Ovarian Endometrioma
11:29

Surgical Techniques to Optimize Ovarian Reserve during Laparoscopic Cystectomy for Ovarian Endometrioma

Published on: January 22, 2022

14.8K

Related Experiment Videos

Last Updated: Dec 2, 2025

Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity
07:20

Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity

Published on: December 21, 2012

16.3K
Ex Vivo Method for Assessing the Mouse Reproductive Tract Spontaneous Motility and a MATLAB-based Uterus Motion Tracking Algorithm for Data Analysis
06:22

Ex Vivo Method for Assessing the Mouse Reproductive Tract Spontaneous Motility and a MATLAB-based Uterus Motion Tracking Algorithm for Data Analysis

Published on: September 1, 2019

9.4K
Surgical Techniques to Optimize Ovarian Reserve during Laparoscopic Cystectomy for Ovarian Endometrioma
11:29

Surgical Techniques to Optimize Ovarian Reserve during Laparoscopic Cystectomy for Ovarian Endometrioma

Published on: January 22, 2022

14.8K

Area of Science:

  • Gynecology
  • Pain Medicine
  • Neuroscience

Background:

  • Endometriosis affects ~10% of women, causing infertility and chronic pelvic pain.
  • Current treatment options are limited due to poor understanding of pain mechanisms.
  • Research often focuses on lesion development, neglecting pain etiology.

Purpose of the Study:

  • To review clinical and experimental evidence on endometriosis-associated pain mechanisms.
  • To explore the roles of inflammation, neurogenic inflammation, neuroangiogenesis, and sensitization.
  • To examine how co-morbidities like IBS and OAB may arise from cross-organ sensitization.

Main Methods:

  • Literature review of clinical and experimental studies.
  • Analysis of evidence on peripheral and central sensitization.
  • Investigation of shared neural pathways in pelvic organs.

Main Results:

  • Inflammation, neurogenic inflammation, and neuroangiogenesis are key contributors to endometriosis pain.
  • Peripheral and central sensitization play significant roles in chronic pain development.
  • Shared nerve pathways between the colon, bladder, and reproductive tract facilitate co-morbidities.

Conclusions:

  • Understanding pain mechanisms is crucial for developing effective endometriosis treatments.
  • Neuroinflammation and sensitization are central to endometriosis-induced chronic pain.
  • Cross-organ sensitization offers a potential explanation for co-occurring pelvic conditions.