Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

1.1K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.1K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

853
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
853
Autoimmune Disorders01:29

Autoimmune Disorders

1.2K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
1.2K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

977
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
977
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

8.2K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
8.2K
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

2.5K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structure and function of the retinal pigment epithelium.

Handbook of clinical neurology·2026
Same author

Patterns of Inflammation in Experimental Autoimmune Uveitis and Their Correlation to Optical Coherence Tomography Findings in Human Uveitis.

International journal of molecular sciences·2026
Same author

Immunology of Uveitis - From Bench to Bedside.

Klinische Monatsblatter fur Augenheilkunde·2026
Same author

Immunopathology of the Outer Retina: Crosstalk With the Immune System.

American journal of ophthalmology·2026
Same author

Case Report: Treating one autoimmune disease induces another: the paradox of TNF-alpha inhibitor therapies.

Frontiers in immunology·2025
Same author

A novel platform for engineered AAV-based vaccines.

Molecular therapy. Methods & clinical development·2025
Same journal

Safety and immunogenicity of an adjuvanted human onchocerciasis vaccine candidate, <i>Ov</i>MANE1: preclinical evaluation in a mice model.

Clinical & translational immunology·2026
Same journal

Early brain-penetrant immunotherapy reverses interferon signature and improves motor outcome in a case of ADAR1-related Aicardi-Goutières syndrome.

Clinical & translational immunology·2026
Same journal

Clinical, biological and cytometric characteristics of two patients with a homozygous A91V<i>PRF1</i> mutation.

Clinical & translational immunology·2026
Same journal

Effect of CXCR5, PD-1 and ICOS on B-cell responses and relevance to myasthenia gravis.

Clinical & translational immunology·2026
Same journal

Development and functional adaptation of intestinal macrophages across the lifespan.

Clinical & translational immunology·2026
Same journal

Myeloid HDAC7 drives liver inflammation and systemic glucose dysregulation during diet-induced obesity.

Clinical & translational immunology·2026
See all related articles

Related Experiment Video

Updated: Dec 2, 2025

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.5K

Is glaucoma an autoimmune disease?

Denis Wakefield1, Gerhild Wildner2

  • 1School of Medical Science UNSW and NSWHP Sydney NSW Australia.

Clinical & Translational Immunology
|November 2, 2020
PubMed
Summary
This summary is machine-generated.

Glaucoma may be an autoimmune disease, with evidence of heat-shock protein responses in patients and animal models. This suggests new diagnostic and treatment approaches for glaucoma.

Keywords:
autoimmunityglaucomaimmunologyimmunotherapy

More Related Videos

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
07:40

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

5.7K
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.7K

Related Experiment Videos

Last Updated: Dec 2, 2025

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.5K
Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
07:40

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

5.7K
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.7K

Area of Science:

  • Immunology
  • Ophthalmology
  • Neuroscience

Background:

  • Glaucoma is a leading cause of irreversible blindness worldwide.
  • Increasing evidence suggests a potential autoimmune basis for glaucoma.
  • Heat-shock proteins (HSPs) are implicated in autoimmune responses.

Purpose of the Study:

  • To explore the hypothesis that glaucoma has autoimmune origins.
  • To review evidence for autoimmune involvement in human and animal models of glaucoma.

Main Methods:

  • Review of existing animal and human studies on glaucoma and autoimmunity.
  • Analysis of immune responses, including antibodies and T-cells, to heat-shock proteins (HSPs).
  • Examination of neurodegenerative changes and immune cell infiltration in the optic nerve.

Main Results:

  • Antibodies and T-cell responses to HSPs are detected in some glaucoma patients and animal models.
  • Animal models exhibit optic nerve neurodegeneration with immunoglobulin and T-cell infiltration, mirroring human disease.
  • Evidence supports an autoimmune component in glaucoma pathogenesis.

Conclusions:

  • The autoimmune hypothesis for glaucoma is supported by accumulating evidence.
  • While not all glaucoma cases are definitively autoimmune, the implications for diagnosis and treatment are significant.
  • Further research is needed to fully elucidate the role of autoimmunity in glaucoma and its clinical impact.