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Changes of inflammatory cytokines in vertebral compression fractures patients with percutaneous balloon kyphoplasty
Jian Zhang1, Yanchun Xu2, Weiwei Lu3
1Department of Neurosurgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Chongming Branch, Shanghai, PR China.
Insights
Percutaneous balloon kyphoplasty (PKP) effectively reduces inflammatory cytokines like IL-6, IL-1β, and TNF-α in osteoporotic vertebral compression fracture patients. Interleukin-6, TNF-α, and anterior height predict successful PKP outcomes.
Area of Science:
- Orthopedics
- Inflammation Research
- Surgical Outcomes
Background:
- Osteoporotic vertebral compression fractures (OVCF) cause significant pain and disability.
- Percutaneous balloon kyphoplasty (PKP) is a common treatment for OVCF.
- The impact of PKP on inflammatory markers and predictive factors for success requires further investigation.
Purpose of the Study:
- To evaluate changes in serum cytokines before and after PKP in OVCF patients.
- To identify prognostic markers for predicting response to PKP.
- To correlate clinical outcomes with cytokine levels and spinal parameters post-PKP.
Main Methods:
- A cohort of 72 patients with single-level lumbar OVCF undergoing PKP were analyzed.
- Patients were categorized into effective and ineffective treatment groups based on outcomes.
- Serum levels of IL-1β, IL-6, and TNF-α, along with spinal height, kyphotic angle, VAS, and ODI scores, were measured pre- and post-PKP.
Main Results:
- The effective group showed significantly improved anterior and posterior vertebral heights, reduced kyphotic angle, VAS, and ODI scores compared to the ineffective group.
- Serum levels of IL-1β, IL-6, and TNF-α significantly decreased post-PKP in the effective group.
- Logistic regression identified IL-6, TNF-α, and anterior height as significant predictors of successful PKP outcomes.
Conclusions:
- PKP effectively reduces pro-inflammatory cytokines (IL-6, IL-1β, TNF-α) in patients with OVCF.
- Serum IL-6, TNF-α levels, and anterior vertebral height are significant predictors of treatment success after PKP.
- These findings suggest a role for inflammatory markers in assessing PKP efficacy and patient selection.
Abstract:
Objective: To explore the changes of a series of cytokines before and after percutaneous balloon kyphoplasty (PKP) and prognostic markers for response to PKP.Methods: From 1 January 2019 to 31 May 2019, all single-level lumbar osteoporotic vertebral compression fracture (OVCF) patients diagnosed by MRI who matched the inclusion and exclusion criteria were enrolled in this study. They were classified into the effective group and the ineffective group based on the outcome after PKP. The levels of a series of inflammatory factors and indices of spinal functions were obtained before and after PKP.Results: A total of 72 patients were included in this study, 59 in the effective group and 13 in the ineffective group. The anterior height (AH) and posterior height (PH) were 77.3 ± 11.2% and 91.2 ± 9.3%, respectively, in the effective group after PKP, which were higher than that in the ineffective group (p<.001). While, the Kyphotic angle, visual analog scale (VAS), and Oswestry Disability Index (ODI) score were 9.1 ± 4.3°, 3.1 ± 1.9, and 19.2 ± 4.1 in the effective group, which was lower than that in ineffective group (p<.001). The serum levels of IL-1β, IL-6, and TNF-α were found significantly decreased after treatment in the effective group (p<.05). The logistic regression showed that the levels of IL-6 TNF-α and AH were significant predictor of outcome.Conclusions: Our results demonstrated that PKP can reduce the serum levels of IL-6, IL-1β, and TNF-α, moreover, the IL-6, TNF-α, and AH were significant predictors of outcome.
