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Updated: Dec 2, 2025
14:20
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
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Robust and smart polypeptide-based nanomedicines for targeted tumor therapy
Chao Deng1, Qiang Zhang1, Jiakun Guo1
1Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China.
Advanced Drug Delivery Reviews
|November 2, 2020
Summary
Synthetic polypeptide nanomedicines offer advanced tumor therapy. Dynamic stability, crucial for anti-tumor performance, is achieved through innovative strategies, enhancing efficacy and safety for clinical translation.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Polypeptide-based nanomedicines are advanced platforms for tumor therapy.
- Dynamic stability (stable in circulation, destabilized in tumor) is vital for nanomedicine anti-tumor performance.
- Several polypeptide nanodrugs are in clinical trials.
Purpose of the Study:
- To review strategies for designing dynamically stabilized polypeptide-based nanomedicines.
- To highlight advancements in robust and smart nanodrugs for targeted cancer treatment.
- To discuss the clinical translation potential of dynamic nanomedicines.
Main Methods:
- Crosslinking nanovehicles with stimuli-responsive linkers (acid, ROS, GSH, photo-sensitive).
- Inter-crosslinking between nanovehicles and drugs.
- Incorporating π-π stacking or lipid-lipid interactions.
- Chemically conjugating drugs to nanovehicles.
- Forming unimolecular micelles.
Main Results:
- Dynamically stabilized nanomedicines show improved tumor targetability.
- Enhanced anti-tumor efficacy and safety profiles observed in various tumor models.
- These strategies lead to robust and smart nanodrugs.
Conclusions:
- Innovative strategies create robust and smart polypeptide nanomedicines.
- Dynamic nanomedicines demonstrate significant potential in preclinical studies.
- Further clinical translation of dynamic nanomedicines is anticipated.
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