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Recent advances in low-frequency Raman spectroscopy for pharmaceutical applications
Kārlis Bērziņš1, Sara J Fraser-Miller1, Keith C Gordon1
1The Dodd-Walls Centre for Photonic and Quantum Technologies, Department of Chemistry, University of Otago, Dunedin 9016, New Zealand.
International Journal of Pharmaceutics
|November 2, 2020
Summary
Low-frequency Raman (LFR) spectroscopy offers unique insights into solid-state properties by analyzing crystallinity. Recent advancements have revitalized LFR, making it a popular tool for pharmaceutical analysis.
Area of Science:
- Solid-state chemistry
- Spectroscopic analysis
- Pharmaceutical sciences
Background:
- Low-frequency Raman (LFR) spectroscopy analyzes vibrational modes linked to long-range order and crystallinity.
- Instrumentation and data analysis advancements have overcome previous limitations of LFR.
- LFR spectroscopy is experiencing increased popularity across various research fields.
Purpose of the Study:
- To provide a comprehensive review of established and emerging LFR applications in pharmaceutical analysis.
- To detail the underlying theory, instrumentation, and data analysis techniques for LFR.
- To highlight the utility of chemometric and computational methods in LFR data analysis.
Main Methods:
- Review of existing literature on LFR spectroscopy.
- Discussion of theoretical principles of LFR.
- Overview of advancements in LFR instrumentation and data processing.
- Exploration of chemometric and computational approaches for LFR data analysis.
Main Results:
- LFR spectroscopy provides unique information on solid-state and structural characteristics, particularly crystallinity.
- Modern instrumentation and data analysis have enhanced LFR's applicability and reliability.
- Numerous established and novel applications of LFR in pharmaceutical analysis are presented.
Conclusions:
- LFR spectroscopy is a valuable technique for characterizing solid-state properties in pharmaceuticals.
- Advancements have made LFR a more accessible and powerful analytical tool.
- The review highlights the broad potential of LFR in pharmaceutical research and development.
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