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Modeling cancer progression using human pluripotent stem cell-derived cells and organoids
Meili Zhang1, J Jeya Vandana2, Lauretta Lacko3
1Department of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY 10065, USA; Department of Medical Genetics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China.
Stem Cell Research
|November 2, 2020
Summary
Human pluripotent stem cells (hPSCs) and organoid technology offer advanced cancer modeling. These models aid in understanding cancer progression, metastasis, and drug discovery.
Area of Science:
- Oncology
- Stem Cell Biology
- Genomics
Background:
- Traditional cancer research relies on cell lines and animal models.
- Human pluripotent stem cells (hPSCs) and organoid technologies are emerging as powerful complementary tools.
- Genome engineering further enhances the utility of these stem cell-based models.
Purpose of the Study:
- To review the application of hPSC and organoid technologies in cancer modeling.
- To discuss their utility in studying cancer cell-of-origin, propagation, and metastasis.
- To explore their potential in drug discovery and understanding cancer heterogeneity.
Main Methods:
- Review of current literature on hPSC and organoid applications in cancer research.
- Analysis of genome engineering techniques used in conjunction with stem cell models.
- Discussion of benefits and challenges of using hPSC-derived models.
Main Results:
- hPSC-derived organoids effectively model cancer progression, including cell-of-origin, propagation, and metastasis.
- These models are valuable for drug discovery, biomarker identification, and mechanistic studies.
- They offer insights into clonal and intra-tumoral heterogeneity.
Conclusions:
- hPSC-derived organoids represent a significant advancement in cancer modeling.
- These models provide a robust platform for recapitulating pathogenic cancer states.
- Their application facilitates drug discovery and a deeper understanding of cancer biology.
