Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Dec 2, 2025

Fabrication of Myogenic Engineered Tissue Constructs

Fabrication of Myogenic Engineered Tissue Constructs

Published on: May 1, 2009

Tissue engineering solutions to replace contractile function during pediatric heart surgery.

Stuart K Williams¹, Ravi K Birla²

¹Bioficial Organs Program, University of Louisville, Louisville, KY, United States.

|November 2, 2020

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Molecular Mechanisms Underlying Recurrent Discrete Subaortic Stenosis: Insights from Bioinformatics Analysis of Human Tissue Samples.

The Annals of thoracic surgery·2026

Same author

Shear Stress Initiates Endothelial-to-Mesenchymal Transition in Endocardial Endothelial Cells.

Annals of biomedical engineering·2026

Same author

Insights into the molecular mechanism of pulmonary vein stenosis in pediatric patients with congenital heart disease.

JTCVS open·2025

Same author

Shear-Induced Macrophage Secretome Promotes Endothelial Permeability.

bioRxiv : the preprint server for biology·2025

Same author

Shear Stress Conditioning Promotes a Pro-Inflammatory Response in Porcine Endocardial Endothelial Cells.

Annals of biomedical engineering·2025

Same author

Noninvasive Measurement of EKG Properties of 3D Artificial Heart Muscle.

AIMS cell and tissue engineering·2025

Same journal

Single-cell transcriptomic profiling identifies TIMP1 as a diagnostic marker linked to macrophage ferroptosis in ulcerative colitis.

Tissue & cell·2026

Same journal

From lab to life: Advances in tissue engineering and 3D bioprinting for regenerative female reproductive health.

Tissue & cell·2026

Same journal

Morphological and ultrastructural characterization of the male accessory glands in Moechotypa diphysis (Coleoptera: Cerambycidae).

Tissue & cell·2026

Same journal

Annexin A1 regulates intestinal epithelial homeostasis and NLRP3-associated signaling in experimental type 1 diabetes.

Tissue & cell·2026

Same journal

CD38-driven NAD⁺ depletion governs crypt structure and barrier dysfunction in fluorouracil-induced colonic mucositis: From metabolic collapse to architectural remodeling.

Tissue & cell·2026

Same journal

Dual regulatory roles and mechanisms of Gamma delta T cells in organ fibrosis.

Tissue & cell·2026

See all related articles

Tissue engineering offers new solutions for pediatric heart surgery. This innovative technology aims to create functional cardiac tissues, potentially revolutionizing treatments for congenital heart abnormalities in children.

Area of Science:

Biomedical Engineering
Regenerative Medicine
Pediatric Cardiology

Background:

Pediatric heart surgery faces significant challenges due to small heart size and complex congenital abnormalities.
Current surgical options are limited, necessitating novel approaches for functional restoration.
There is a critical need for advanced tools to address the unique demands of pediatric cardiac repair.

Purpose of the Study:

To explore the potential of tissue engineering in pediatric heart surgery.
To highlight the development of functional cardiac tissues for pediatric applications.
To provide insights into novel therapeutic strategies for congenital heart defects.

Main Methods:

Review of current tissue engineering strategies for cardiac applications.

Keywords:

Fontan pumps HLHS Pediatric heart surgery Single ventricle

More Related Videos

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets

Published on: October 3, 2014

Neonatal Cardiac Scaffolds: Novel Matrices for Regenerative Studies

Neonatal Cardiac Scaffolds: Novel Matrices for Regenerative Studies

Published on: November 5, 2016

Related Experiment Videos

Last Updated: Dec 2, 2025

Fabrication of Myogenic Engineered Tissue Constructs

Fabrication of Myogenic Engineered Tissue Constructs

Published on: May 1, 2009

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets

Published on: October 3, 2014

Neonatal Cardiac Scaffolds: Novel Matrices for Regenerative Studies

Neonatal Cardiac Scaffolds: Novel Matrices for Regenerative Studies

Published on: November 5, 2016

Analysis of fabricating contractile heart muscle, ventricles, and Fontan pumps.

Evaluation of transplantable tissue equivalents for pediatric use.

Main Results:

Tissue engineering can fabricate various cardiac components, including contractile muscle and ventricles.
Transplantable tissue equivalents show promise for providing functional cardiac tissue.
This technology offers a potential game-changer for pediatric heart surgeons.

Conclusions:

Tissue engineering presents a promising toolkit for pediatric heart surgeons.
It holds significant implications for replacing lost contractile function in pediatric patients.
This approach could revolutionize the treatment of congenital heart abnormalities.