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A Semi-Quantitative Drug Affinity Responsive Target Stability DARTS assay for studying Rapamycin/mTOR interaction
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Bioproperties, Nanostructured System and Analytical and Bioanalytical Methods for Determination of Rapamycin: A

Karen Cristina Dos Santos1, Leidiana Rocha Dos Reis1, Camila Fernanda Rodero1

  • 1School of Pharmaceutical Sciences, São Paulo State University (UNESP), São Paulo, Brazil.

Critical Reviews in Analytical Chemistry
|November 3, 2020
PubMed

Insights

This review covers rapamycin, an mTOR inhibitor used in cancer therapy and as an immunosuppressant. It highlights nanomedicine approaches for drug delivery and analytical methods for rapamycin quantification.

Area of Science:

  • Pharmacology
  • Oncology
  • Nanomedicine
  • Analytical Chemistry

Background:

  • Rapamycin is a potent mTOR inhibitor impacting cell proliferation and immune response.
  • It is utilized in cancer treatment and investigated for enhanced delivery via nanomedicine.
  • Accurate quantification of rapamycin is crucial for therapeutic monitoring.

Purpose of the Study:

  • To review current research on rapamycin, focusing on nanomedicine applications.
  • To summarize analytical methodologies for rapamycin identification and quantification.
  • To consolidate information on rapamycin's role in cancer and immunosuppression.

Main Methods:

  • Literature review of scientific works on rapamycin.
  • Analysis of studies involving nanostructured drug delivery systems for rapamycin.
  • Examination of various analytical techniques including HPLC, mass spectrometry, and immunoassays.

Main Results:

  • Rapamycin's efficacy as an mTOR inhibitor and its use in cancer therapy are well-established.
  • Nanomedicine offers promising strategies to improve rapamycin's bioavailability and efficacy.
  • Advanced analytical techniques are essential for sensitive and accurate rapamycin detection.

Conclusions:

  • Rapamycin remains a significant therapeutic agent, particularly in oncology.
  • Nanotechnology advancements are crucial for optimizing rapamycin drug delivery.
  • Continued development of sensitive analytical methods is vital for rapamycin's clinical application.
Keywords:
Rapamycinanalytical methodsdrug delivery

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