Circular RNA hsa_circ_0007364 increases cervical cancer progression through activating methionine adenosyltransferase...

Area of Science:

• Oncology
• Molecular Biology
• Genetics

Background:

• Circular RNAs (circRNAs) are increasingly recognized for their roles in cancer development.
• The specific function of hsa_circ_0007364 in cervical cancer (CC) pathogenesis was previously undefined.

Purpose of the Study:

• To investigate the role and molecular mechanisms of hsa_circ_0007364 in cervical cancer.
• To determine if hsa_circ_0007364 could serve as a potential therapeutic target for CC.

Main Methods:

• Bioinformatics analysis and experimental validation were employed.
• Cell proliferation, invasion assays, and in vivo tumor growth studies were conducted.
• RNA immunoprecipitation and Western blot analyses were used to elucidate molecular interactions.

Main Results:

• Hsa_circ_0007364 was found to be upregulated in CC tissues and associated with advanced clinical features.
• Inhibition of hsa_circ_0007364 suppressed CC cell proliferation and invasion in vitro and reduced tumor growth in vivo.
• Hsa_circ_0007364 acts as a molecular sponge for miR-101-5p, and the miR-101-5p/MAT2A axis was identified as a key regulatory pathway.

Conclusions:

• Hsa_circ_0007364 functions as an oncogenic circRNA in cervical cancer progression.
• The hsa_circ_0007364/miR-101-5p/MAT2A axis represents a novel regulatory pathway in CC.
• Hsa_circ_0007364 inhibition presents a potential therapeutic strategy for cervical cancer treatment.