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Updated: Dec 2, 2025

Chemical Dimerization-Induced Protein Condensates on Telomeres
Published on: April 12, 2021
Protein phase separation and its role in tumorigenesis
Shan Jiang1, Johan Bourghardt Fagman2, Changyan Chen3
1Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden.
Abstract:
Cancer is a disease characterized by uncontrolled cell proliferation, but the precise pathological mechanisms underlying tumorigenesis often remain to be elucidated. In recent years, condensates formed by phase separation have emerged as a new principle governing the organization and functional regulation of cells. Increasing evidence links cancer-related mutations to aberrantly altered condensate assembly, suggesting that condensates play a key role in tumorigenesis. In this review, we summarize and discuss the latest progress on the formation, regulation, and function of condensates. Special emphasis is given to emerging evidence regarding the link between condensates and the initiation and progression of cancers.
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