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Assessment of the relationship between death and CHA2DS2-VASc score in peripheral artery disease

Zafer Yalim1, Mustafa Aldemir2, Sümeyra Alan Yalim3

  • 1Department of Cardiology, Faculty of Medicine, Afyonkarahisar Health Science University, Afyonkarahisar, Turkey - zaferyalm@yahoo.com.tr.

International Angiology : a Journal of the International Union of Angiology
|November 3, 2020
PubMed

Insights

The CHA2DS2-VASc score, used for atrial fibrillation, predicts mortality in peripheral arterial disease (PAD) patients. Higher scores indicate increased risk, suggesting its utility in identifying high-risk PAD individuals.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Risk Stratification

Background:

  • The CHA2DS2-VASc score assesses thromboembolic risk in atrial fibrillation (AF).
  • Its predictive value extends to various diseases beyond AF, including coronary artery disease and stroke.
  • The score's utility in predicting mortality for peripheral arterial disease (PAD) patients remains unexplored.

Purpose of the Study:

  • To evaluate the predictive capability of the CHA2DS2-VASc score for mortality in patients diagnosed with PAD.
  • To determine if the CHA2DS2-VASc score can serve as a prognostic tool for PAD outcomes.

Main Methods:

  • A cohort of 396 incident PAD patients was analyzed.
  • Patients were categorized into deceased (N.=153) and living (N.=243) groups.
  • Receiver operating characteristic (ROC) analysis and Kaplan-Meier survival analysis were employed to assess predictive accuracy and event timing.

Main Results:

  • The CHA2DS2-VASc scores were significantly higher in the deceased group (4.37±0.1) compared to the living group (2.96±0.9).
  • A significant positive correlation was found between CHA2DS2-VASc score and mortality (Spearman R:0.454, P<0.001).
  • Multivariate analysis identified CHA2DS2-VASc score (OR: 1.81), Stroke (OR: 0.43), and CRP (OR: 1.04) as independent predictors of death.

Conclusions:

  • The CHA2DS2-VASc score demonstrates a direct relationship with mortality risk in PAD patients.
  • This score offers a practical method for identifying high-risk individuals within the PAD population.
  • Further research is warranted to fully elucidate the role of the CHA2DS2-VASc score in managing PAD.
Abstract

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