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Salivary metabolomics for cancer detection
1Research and Development Centre for Minimally Invasive Therapies, Medical Research Institute, Tokyo Medical University , Tokyo, Japan.
Expert Review of Proteomics
|November 3, 2020
Summary
Salivary metabolomics analysis shows promise for detecting oral and systemic cancers through noninvasive saliva screening. Establishing standard protocols is crucial for reproducible results in clinical applications.
Area of Science:
- Metabolomics
- Cancer Detection
- Biofluid Analysis
Background:
- Saliva offers a noninvasive method for disease screening.
- Salivary metabolomics analysis is emerging as a tool for detecting oral and systemic cancers.
Purpose of the Study:
- To review the technical aspects and applications of salivary metabolomics for cancer detection.
- To discuss strategies for establishing standard operating protocols for reproducible quantification data.
Main Methods:
- Review of preconditioning effects, sample collection, storage, processing, and measurement.
- Analysis of data and validation of results.
- Examination of the relationship between salivary biomarkers and distant tumors.
Main Results:
- Salivary metabolomics reflects both oral and systemic health status, indicating potential for cancer detection.
- The sensitivity and specificity of individual and combined markers have been evaluated.
- A validation study is required to confirm findings.
Conclusions:
- Salivary metabolomics is a potent tool for cancer detection, reflecting overall health.
- Standard operating protocols are essential for reproducible data before clinical implementation.
- Further validation studies are necessary for widespread clinical use.
