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How to approach flow chemistry.

Mara Guidi1, Peter H Seeberger, Kerry Gilmore

  • 1Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam, Germany. kerry.m.gilmore@uconn.edu.

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Summary

Flow chemistry offers reproducible access to chemical processes. This work redefines flow modules as transformers or generators, enabling robust chemical assembly systems (CAS) for diverse synthesis.

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Area of Science:

  • Organic Chemistry
  • Chemical Engineering
  • Process Chemistry

Background:

  • Flow chemistry provides reproducible access to chemical processes.
  • Traditional flow modules are defined by external activation/control methods.
  • Simplifying flow chemistry teaching and dissemination is a key goal.

Purpose of the Study:

  • To redefine flow modules based on induced chemical effect for synthetic relevance.
  • To introduce a new classification of flow modules: transformers and generators.
  • To guide the design of robust flow modules and chemical assembly systems (CAS).

Main Methods:

  • Conceptual redefinition of flow chemistry modules.
  • Classification of modules into transformers (specific transformations) and generators (reactive intermediates).
  • Discussion of module design principles for substrate independence and robustness.

Main Results:

  • Proposed two subclasses of flow modules: transformers and generators.
  • Demonstrated that module chemistry should ideally be substrate-independent.
  • Highlighted the potential for connecting modules into reconfigurable chemical assembly systems (CAS).

Conclusions:

  • Redefined flow modules simplify teaching and application of flow chemistry.
  • Transformers and generators offer a synthetically relevant approach to flow module design.
  • Chemical assembly systems (CAS) enable efficient synthesis of targeted compounds and libraries.