Studying the cellular distribution of highly phototoxic platinated metalloporphyrins using isotope labelling
Riccardo Rubbiani1, Wenyu Wu, Anu Naik
1Department of Chemistry, University of Zurich, Zurich CH 8057, Switzerland. spingler@chem.uzh.ch.
Chemical Communications (Cambridge, England)
|November 3, 2020
Abstract:
Novel tetraplatinated metalloporphyrin-based photosensitizers (PSs) are reported, which show excellent phototoxic indexes (PIs) up to 5800 against HeLa cells, which is, to the best of our knowledge, the highest value reported for any porphyrin so far. Furthermore, 67Zn isotope labelling allowed the determination of the ratio of zinc to platinum inside the cells using ICP-MS.
