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Related Concept Videos

Proteomics01:33

Proteomics

9.0K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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An Aquatic Microbial Metaproteomics Workflow: From Cells to Tryptic Peptides Suitable for Tandem Mass Spectrometry-based Analysis
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Are we forgetting the "proteomics" in multi-omics ecotoxicology?

Xuefang Liang1, Christopher J Martyniuk2, Denina B D Simmons3

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Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
|November 3, 2020
PubMed
Summary

Proteomics is crucial for understanding chemical exposure effects in toxicology. This review emphasizes integrating proteomics into multi-omics studies for accurate adverse outcome pathway development and chemical risk assessment.

Keywords:
Adverse outcome pathwaysChemical exposureComputational biologyEnvironmental toxicologyOmicsStressors

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Area of Science:

  • Environmental toxicology
  • Proteomics
  • Comparative ecotoxicology

Background:

  • Proteomics offers direct insight into toxicological mechanisms, unlike transcriptomics.
  • Proteins are key mediators of phenotype and molecular initiating events in adverse outcome pathways (AOPs).
  • Current multi-omics approaches may underutilize proteomics, potentially limiting toxicological insights.

Purpose of the Study:

  • To highlight the critical role of proteomics in environmental toxicology and multi-omics research.
  • To advocate for increased utilization of proteomics in developing adverse outcome pathways (AOPs).
  • To discuss challenges and opportunities for proteomics in ecotoxicology and chemical risk assessment.

Main Methods:

  • Critical review of existing literature on proteomics in toxicology.
  • Analysis of multi-omics case studies incorporating proteomics.
  • Discussion of proteomics' strengths and limitations within comparative ecotoxicology.

Main Results:

  • Proteins, not transcripts, are direct mediators of phenotypic responses to chemical exposures.
  • Proteomics can identify novel molecular initiating events (MIEs) and key events (KEs) for AOPs.
  • Integration of proteomics enhances the accuracy of toxicological assessments and risk evaluations.

Conclusions:

  • Proteomics is essential for a comprehensive understanding of chemical impacts in environmental toxicology.
  • Wider acceptance and inclusion of proteomics are needed in multi-omics studies and AOP development.
  • Further research into proteomics applications can advance chemical risk assessment and ecotoxicological studies.