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Myxoid Liposarcoma with Cartilagenous Differentiation
Hina Tariq1, Tariq Sarfraz2, Iqra Saeed1
1Department of Histopathology, Army Medical College, Rawalpindi, Pakistan.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|November 4, 2020
Summary
This study reports the 8th case of myxoid liposarcoma (MLPS) with cartilaginous differentiation, a rare occurrence. Awareness of this diverse morphology is crucial for accurate diagnosis of this adipocytic tumor.
Area of Science:
- Oncology
- Pathology
- Surgical Oncology
Background:
- Myxoid liposarcoma (MLPS) is the second most common type of liposarcoma, characterized by a diverse histological spectrum.
- Heterologous differentiation in MLPS is rare, with only seven previously reported cases exhibiting cartilaginous differentiation.
Observation:
- The study presents the 8th documented case of MLPS with significant cartilaginous differentiation in a 66-year-old female with a posterior left thigh mass.
- Microscopic examination revealed typical MLPS features alongside approximately 20% of the tumor volume showing mature hyaline cartilage.
- The tumor exhibited involved anterior and lateral margins, with other margins being very close to the tumor, indicating potential for local recurrence.
Findings:
- The final diagnosis was MLPS with prominent cartilaginous differentiation, graded as FNCLCC grade 1 and staged provisionally as pT2.
- Cytogenetic analysis was not mentioned for this specific case but has confirmed previous cases.
Implications:
- Accurate diagnosis of MLPS requires awareness of its varied histological presentations, including rare heterologous differentiation like cartilaginous changes.
- The findings highlight the importance of thorough pathological examination and surgical planning for MLPS with cartilaginous differentiation to ensure complete tumor resection.
- Further research into the genetic and molecular underpinnings of heterologous differentiation in MLPS may improve diagnostic accuracy and treatment strategies.
