Related Experiment Video

Updated: Dec 2, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

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Dominant Antibiotic Consumption Patterns Might Be Associated With the Prevalence of Multiple Sclerosis in European

GÁbor TernÁk1, KÁroly BerÉnyi2, Gergely MÁrovics2

  • 1Medical School, Institute of Migration Health, University of Pécs, Pécs, Hungary gabor.ternak@aok.pte.hu.

In Vivo (Athens, Greece)
|November 4, 2020
PubMed
Abstract

Insights

Antibiotic use, particularly narrow spectrum penicillin and tetracycline, may be linked to higher multiple sclerosis (MS) prevalence. This study explored the controversial association between antibiotic consumption and MS globally.

Area of Science:

  • Neurology
  • Epidemiology
  • Pharmacology

Background:

  • Multiple sclerosis (MS) affects millions globally, with a prevalence of 50-300 per 100,000 people.
  • The relationship between antibiotic use and MS development or prevention remains debated.
  • Understanding potential environmental factors like antibiotic consumption is crucial for MS research.

Purpose of the Study:

  • To investigate the association between antibiotic consumption patterns and multiple sclerosis (MS) prevalence.
  • To determine if specific antibiotic classes correlate with higher MS rates across European countries.

Main Methods:

  • Utilized Pearson statistical comparisons to analyze data from 30 European countries.
  • Examined annual average antibiotic consumption (Defined Daily Dose/1,000 inhabitants/Day) from 1997-2018.
  • Correlated antibiotic consumption data with MS prevalence estimates for 2016.

Main Results:

  • A positive correlation was found between the consumption of narrow spectrum penicillin and MS prevalence (r=0.636).
  • Tetracycline consumption also showed a positive association with MS prevalence (r=0.412).
  • These findings suggest a potential promoting effect of these antibiotics on MS.

Conclusions:

  • Countries with higher consumption of narrow spectrum penicillin and tetracycline exhibit increased multiple sclerosis prevalence.
  • The study highlights a potential link between specific antibiotic usage and MS epidemiology.
  • Further research is warranted to confirm causality and explore underlying mechanisms.
Keywords:
Antibiotic consumptionmultiple sclerosispenicillintetracycline

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