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Human Dorsal Root Ganglion Stimulation Reduces Sympathetic Outflow and Long-Term Blood Pressure
Yrsa B Sverrisdottir1,2,3, Sean C Martin1,4, George Hadjipavlou4
1Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
JACC. Basic to Translational Science
|November 4, 2020
Summary
Dorsal root ganglion (DRG) stimulation effectively reduced sympathetic nerve activity and lowered blood pressure, particularly with left-sided application. This suggests DRG stimulation
Area of Science:
- Neuroscience
- Cardiovascular Physiology
Background:
- Autonomic dysfunction contributes to cardiovascular diseases like hypertension and heart failure.
- Modulating sympathetic nerve activity is a therapeutic target for these conditions.
Purpose of the Study:
- To investigate the effects of dorsal root ganglion (DRG) stimulation on sympathetic nerve activity and hemodynamic parameters.
- To assess the potential of DRG stimulation for treating autonomic disorders.
Main Methods:
- Direct recording of muscle sympathetic nerve activity (MSNA) during DRG stimulation (ON and OFF).
- Simultaneous measurement of hemodynamic variables, including blood pressure.
- Comparison of stimulation effects between left and right DRG.
Main Results:
- DRG stimulation significantly decreased MSNA firing frequency.
- Significant reductions in blood pressure were observed with DRG stimulation.
- Left-sided DRG stimulation demonstrated greater reductions in sympathetic activity and blood pressure.
Conclusions:
- DRG stimulation effectively reduces sympathetic nerve activity and lowers blood pressure.
- Left-sided DRG stimulation may induce beneficial long-term phenotypic changes.
- DRG stimulation shows promise for treating de novo autonomic disorders such as hypertension and heart failure.
Keywords:
BF, burst frequencyBI, burst incidenceBP, blood pressureDBP, diastolic blood pressureDRG stimulationDRG, dorsal root ganglionDRGS, dorsal root ganglion stimulationHR, heart rateMAP, mean arterial pressureMME, morphine milligram equivalentMRBA%, median relative burst amplitudeMSNA, muscle sympathetic nerve activitySBP, systolic blood pressureSCS, spinal cord stimulationVAS, visual analogue score of painblood pressurehypertensionneuromodulationsympathetic nerve activity
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