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Calcitriol Suppresses Platelet Activation and Thrombosis, Mitigating Cardiovascular Risks in Metabolic
Peng Zhang1, Huajie Xu2, Shujing Wu3
1Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China; Institutes of Biomedical Sciences, Fudan University, Shanghai, China; National Clinical Research Center for Interventional Medicine, Zhongshan Hospital, Fudan University, Shanghai, China; State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China; NHC Key Laboratory of Ischemic Heart Diseases, Zhongshan Hospital, Fudan University, Shanghai, China; Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Zhongshan Hospital, Fudan University, Shanghai, China.
None:
Metabolic dysfunction-associated steatotic liver disease is associated with vitamin D deficiency, and platelets exhibit hyperactivity. Zhang et al provide novel insights into the mechanisms underlying platelet hyperreactivity and thrombotic risk in patients with metabolic dysfunction-associated steatotic liver disease, demonstrating that calcitriol activates the vitamin D receptor in megakaryocytes and platelets, leading to the downregulation of P2Y12 expression and the modulation of the cyclic adenosine monophosphate/protein kinase A and mitogen-activated protein kinase signaling pathways, thereby attenuating platelet activation.
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