Cd-Based Metal-Organic Framework for Selective Turn-On Fluorescent DMSO Residual Sensing

Area of Science:

• Materials Science
• Analytical Chemistry
• Supramolecular Chemistry

Background:

• Dimethyl sulfoxide (DMSO) is a common solvent in chemical synthesis, and its residual presence on products is difficult to detect.
• Complete removal of DMSO is crucial for ensuring chemical product purity.

Purpose of the Study:

• To develop a sensitive and selective method for detecting trace amounts of residual DMSO.
• To report a novel cadmium(II) metal-organic framework (MOF), SXU-4, as a luminescent probe for DMSO detection.

Main Methods:

• Fluorescence spectroscopy was employed to investigate the interaction between SXU-4 and DMSO.
• Crystallographic characterization of DMSO-loaded SXU-4 (DMSO@SXU-4) was performed.
• Computational methods were used to understand the mechanism of fluorescence enhancement.

Main Results:

• SXU-4 exhibits a highly selective and sensitive 'turn-on' fluorescence response to DMSO.
• The MOF probe can effectively detect trace DMSO in various solvents.
• Crystallographic and computational data revealed enhanced DMSO-MOF conjugation and charge rearrangement as causes for fluorescence intensification.

Conclusions:

• The MOF SXU-4 serves as an effective luminescent probe for the rapid detection of residual DMSO.
• This method facilitates quick purity assessment of chemical products by analyzing washing solutions.
• The findings provide insights into the mechanism of fluorescence enhancement in MOF-analyte interactions.