Related Experiment Video
Updated: Dec 2, 2025

Imine Metathesis by Silica-Supported Catalysts Using the Methodology of Surface Organometallic Chemistry
Published on: October 18, 2019
Electrochemical-Induced Transfer Hydrogenation of Imidazopyridines with Secondary Amine as Hydrogen Donor
Jiangwei Wen1, Hongyun Qin1, Kelu Yan1
1Institute of Medicine and Materials Applied Technologies, College of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, Shandong 273165, P. R. China.
Abstract:
Electrochemical-induced transfer hydrogenation (TH) of N-heteroaromatic to construct biologically active functional molecule is an appealing and yet challenging task. We report herein the first selective transfer hydrogenation of imidazopyridine derivatives with secondary amines as the hydrogen donors under electrochemical conditions. The successful conversion of cathode transfer hydrogenation depends on the solvation effect. Importantly, such electrochemical-induced transfer hydrogenation can be easily amplified with excellent efficiency.
Related Concept Videos
Aldehydes and Ketones with Amines: Imine Formation Mechanism
Imines are formed under mildly acidic conditions. A pH of 4.5 is ideal for the reaction.
If the pH is low or the solution is too acidic, the reaction slows down in the...
Preparation of 1° Amines: Azide Synthesis
Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
Aldehydes and Ketones with Amines: Imine and Enamine Formation Overview
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
Preparation of Amines: Reductive Amination of Aldehydes and Ketones
Nitriles to Amines: LiAlH4 Reduction
As shown below, the mechanism involves three steps. Firstly, the hydride ion acting as a nucleophile attacks the nitrile carbon to form an anion. In the second step, a second equivalent of the hydride ion attacks the anion to...

