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Updated: Dec 2, 2025
13:21
Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
Published on: July 21, 2011
15.2K
Supramolecular coordination complexes as diagnostic and therapeutic agents
Guocan Yu1, Meijuan Jiang1, Feihe Huang2
1Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, United States.
Current Opinion in Chemical Biology
|November 4, 2020
Summary
Supramolecular coordination complexes offer advanced metal-based cancer theranostics, addressing limitations of current drugs like cisplatin. These complexes show promise for improved cancer imaging, resistance, and toxicity management.
Area of Science:
- Materials Science
- Medicinal Chemistry
- Nanotechnology
Background:
- Metal-based drugs like cisplatin are mainstays in cancer therapy but face challenges including poor pharmacokinetics, drug resistance, and severe side effects.
- The development of new metal-based anticancer therapeutics has been slow, hindering clinical progress.
- Supramolecular coordination complexes offer a modular platform for integrating diagnostic and therapeutic functions for precise cancer theranostics.
Purpose of the Study:
- To review recent advancements in supramolecular coordination complexes for cancer theranostics.
- To highlight strategies for overcoming limitations of current metal-based anticancer drugs.
- To focus on sophisticated ligands and nanoformulations for improved cancer diagnosis and treatment.
Main Methods:
- Review of recent scientific literature on supramolecular coordination complexes in cancer research.
- Analysis of strategies for developing novel coordination ligands.
- Examination of nanoformulation approaches for metal-based agents.
Main Results:
- Supramolecular coordination complexes demonstrate potential for precise cancer theranostics by incorporating diagnostic and therapeutic modalities.
- Novel ligands and nanoformulations are being developed to address issues like poor pharmacokinetics, multidrug resistance, and toxicity.
- These advanced materials show promise for improving imaging capabilities and overcoming pharmacological deficiencies in cancer treatment.
Conclusions:
- Supramolecular coordination complexes represent a promising frontier in developing next-generation metal-based cancer therapeutics.
- The modular nature of these complexes facilitates the integration of advanced functionalities for enhanced cancer theranostics.
- Continued research into sophisticated ligands and nanoformulations is crucial for realizing the full potential of these agents in clinical oncology.
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